Molecular Structure
Lapatinib, Inhibitor
Lapatinib
Purity
>98% (TLC); NMR (Conforms)
Synonyms
Lapatinib; Fasudil HCl; 1-(5-Isoquinolinesulfonyl)homopiperazine HCl; HA-1077; inhibitor
Purity/Purification
>98% (TLC); NMR (Conforms)
Form/Format
Yellow powder
CAS Number
231277-92-2
Molecular Formula
C29H26ClFN4O4S
Melting Point
136-140 degree C
Activity
ROCK inhibitor
Reconstitution
May be dissolved in DMSO (75 mg/ml); or Water (100 mg/ml)
Solubilization
Soluble in DMSO (200 mg/ml)
Preparation and Storage
Store desiccated as supplied at -20 degree C for up to 2 years. Store solutions at -20 degree C for up to 1 month.
Molecular Structure
Molecular Structure
Related Product Information for Lapatinib, inhibitor
EGFR kinase Inhibitor
Rho-associated kinase inhibitor (IC50 = 1.9 M and 10.7 uM for Rho-associated kinase II and Rho-associated kinase respectively)1. Inhibits other kinases including cyclic nucleotide-dependent protein kinases1. Reduces tryptamine-evoked vasopressor responses2. Attenuates bleomycin-induced pulmonary fibrosis in a mouse model3. Clinically useful vasodilator.
Scientific Background: Potent inhibitor of EGFR kinase (Ki=3 nM), Erb-2 kinase (Ki=13 nM) Erb-4 kinase (Ki=347 nM) (1). Clinically useful agent for treatment of breast cancer (2-3). Cell permeable.
Rho-associated kinase inhibitor (IC50 = 1.9 M and 10.7 uM for Rho-associated kinase II and Rho-associated kinase respectively)1. Inhibits other kinases including cyclic nucleotide-dependent protein kinases1. Reduces tryptamine-evoked vasopressor responses2. Attenuates bleomycin-induced pulmonary fibrosis in a mouse model3. Clinically useful vasodilator.
Scientific Background: Potent inhibitor of EGFR kinase (Ki=3 nM), Erb-2 kinase (Ki=13 nM) Erb-4 kinase (Ki=347 nM) (1). Clinically useful agent for treatment of breast cancer (2-3). Cell permeable.
Product Categories/Family for Lapatinib, inhibitor
References
1. SP Davies et al. Biochem. J. 2000 351:95 2. MA Anwar et al. Vascul. Pharmacol. 2013 58:140 3. C Jiang et al. Int. J. Mol. Sci. 2012 13:8293
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Product Notes
The Lapatinib (Catalog #AAA515024) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Lapatinib, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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