Structure
LY 3200882, Inhibitor
LY 3200882
Purity
>98% (HPLC)
Synonyms
LY 3200882; LY3200882; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 85mg/mL (<1mg/mL refers to the product slightly soluble or insoluble)
Target
TGFBR
Receptor
TGF-beta/Smad
Chemical Name
4-[[4-[[1-Cyclopropyl-3-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]oxy]-2-pyridinyl]amino]-alpha, alpha-dimethyl-2-pyridinemethanol
SMILES
CC(O)(C)C1=NC=CC(NC2=NC=CC(OC3=CN(C4CC4)N=C3C5CCOCC5)=C2)=C1
Molecular Formula
C24H29N5O3
CAS Number
1898283-02-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for LY 3200882, inhibitor
LY 3200882 (LY3200882) is a novel potent, highly selective, ATP competitive TGF-beta receptor type 1 (TGFbetaRI, ALK5) inhibitor; potently inhibits TGFbeta mediated SMAD phosphorylation in vitro in tumor and immune cells and in vivo in subcutaneous tumors; LY 3200882 shows potent anti-tumor activity in the orthotopic 4T1-LP model of triple negative breast cancer and this activity correlated with enhanced tumor infiltrating lymphocytes in the tumor microenvironment. Solid Tumors Phase 1 Clinical
Product Categories/Family for LY 3200882, inhibitor
References
1. Huaxing Pei, et al. Abstract 955: LY3200882, a novel, highly selective TGFbetaRI small molecule inhibitor. AACR. DOI: 10.1158/1538-7445.
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Product Notes
The LY 3200882 (Catalog #AAA3602981) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "LY 3200882, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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