Structure
LY2157299, Inhibitor
LY2157299
Purity
>98% (HPLC)
Synonyms
LY2157299; Galunisertib; LY-2157299; LY 2157299; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=47mg/mL
Target
TGFBR
Receptor
TbetaRI
Chemical Name
6-Quinolinecarboxamide, 4-[5, 6-dihydro-2-(6-methyl-2-pyridinyl)-4H-pyrrolo[1, 2-b]pyrazol-3-yl]
SMILES
O=C(C1=CC=C2N=CC=C(C3=C(CCC4)N4N=C3C5=NC(C)=CC=C5)C2=C1)N
Molecular Formula
C22H19N5O
CAS Number
700874-72-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for LY2157299, inhibitor
LY2157299 (Galunisertib) is a potent, specific inhibitor of TGF-beta receptor I kinase ( (TGF-betaRI) with IC50 of 56nM; inhibits TGF-beta-mediated SMAD2 activation and hematopoietic suppression in primary hematopoietic stem cells in a dose-dependent manner, stimulates hematopoiesis from primary MDS bone marrow specimens; ameliorates anemia in a TGF-beta overexpressing transgenic mouse model of bone marrow failure; displays significant antitumor activity against both Calu6 and MX1 xenografts in mice. Blood Cancer Phase 3 Clinical
Product Categories/Family for LY2157299, inhibitor
References
1. Zhou L, et al. Cancer Res. 2011 Feb 1; 71 (3):955-63.
2. Yoon JH, et al. EMBO Mol Med. 2013 Nov; 5 (11):1720-39.
3. Bhola NE, et al. J Clin Invest. 2013 Mar; 123 (3):1348-58.
4. Rodon J, et al. Clin Cancer Res. 2015 Feb 1; 21 (3):553-60.
2. Yoon JH, et al. EMBO Mol Med. 2013 Nov; 5 (11):1720-39.
3. Bhola NE, et al. J Clin Invest. 2013 Mar; 123 (3):1348-58.
4. Rodon J, et al. Clin Cancer Res. 2015 Feb 1; 21 (3):553-60.
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Product Notes
The LY2157299 (Catalog #AAA3605687) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "LY2157299, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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