Structure
AZD-5438, Inhibitor
AZD-5438
Purity
>98% (HPLC)
Synonyms
AZD-5438; AZD 5438; AZD5438; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
CDK
Receptor
CDK1; CDK2; CDK9
Chemical Name
2-Pyrimidinamine, 4-[2-methyl-1-(1-methylethyl)-1H-imidazol-5-yl]-N-[4-(methylsulfonyl)phenyl]
SMILES
O=S(C1=CC=C(NC2=NC=CC(C3=CN=C(C)N3C(C)C)=N2)C=C1)(C)=O
Molecular Formula
C18H21N5O2S
CAS Number
602306-29-6
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for AZD-5438, inhibitor
A potent and oral inhibitor of CDK1/2/9 with IC50 of 16/6/20nM, respectively; also inhibits the kinase activity of p25-Cdk5 (IC50=14nM) and GSK-3beta (IC50=17nM) in vitro, displays 75-fold less active against cyclin D-Cdk4; shows significant antiproliferative activity in human tumor cell lines (IC50 range: 0.2-1.7uM), inhibits the phosphorylation of Cdk substrates pRb, nucleolin, PP1A, and RNA polymerase II COOH-terminal domain and blocks cell cycle; inhibits the human tumor xenograft growth in vivo; also inhibits PASTA kinase in L. monocytogenes (PrkA) and L. monocytogenes growth in a beta-lactam-synergism-dependent manner. Solid Tumors Phase 1 Discontinued
Product Categories/Family for AZD-5438, inhibitor
References
1. Byth KF, et al. Mol Cancer Ther. 2009 Jul; 8 (7):1856-66.
2. Boss DS, et al. Ann Oncol. 2010 Apr; 21 (4):884-94.
3. Pensinger DA, et al. Antimicrob Agents Chemother. 2014 Aug; 58 (8):4486-94.
4. Raghavan P, et al. Int J Radiat Oncol Biol Phys. 2012 Nov 15; 84 (4):e507-14.
2. Boss DS, et al. Ann Oncol. 2010 Apr; 21 (4):884-94.
3. Pensinger DA, et al. Antimicrob Agents Chemother. 2014 Aug; 58 (8):4486-94.
4. Raghavan P, et al. Int J Radiat Oncol Biol Phys. 2012 Nov 15; 84 (4):e507-14.
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Product Notes
The AZD-5438 (Catalog #AAA3605243) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "AZD-5438, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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