Structure
EW-7197, Inhibitor
EW-7197
Purity
>98% (HPLC)
Synonyms
EW-7197; Vactosertib; EW7197; TEW-7197; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
TGFBR
Receptor
ALK1; ALK2; ALK3; ALK4; ALK5
Chemical Name
1H-Imidazole-2-methanamine, N-(2-fluorophenyl)-5-(6-methyl-2-pyridinyl)-4-[1, 2, 4]triazolo[1, 5-a]pyridin-6-yl
SMILES
FC1=CC=CC=C1NCC2=NC(C3=CN4C(C=C3)=NC=N4)=C(C5=NC(C)=CC=C5)N2
Molecular Formula
C22H18FN7
CAS Number
1352608-82-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for EW-7197, inhibitor
EW-7197 (Vactosertib, TEW-7197) is a highly potent, selective inhibitor of TGF-beta type I receptor kinase (ALK5) with IC50 of 11nM; also inhibits ALK4 (IC50=13nM) and shows less potency for p38alpha (IC50=280nM); exhibits no inhibition on ALK1/2/3/6 (>10uM); inhibits Smad/TGFbeta signaling, cell migration, invasion, and lung metastasis in MMTV/c-Neu mice and 4T1 orthotopic-grafted mice; oral bioavailability (Hcl salt). Blood Cancer Phase 1 Clinical
Product Categories/Family for EW-7197, inhibitor
References
1. Jin CH, et al. J Med Chem. 2014 May 22; 57 (10):4213-38.
2. Son JY, et al. Mol Cancer Ther. 2014 Jul; 13 (7):1704-16.
3. Yoon JH, et al. EMBO Mol Med. 2013 Nov; 5 (11):1720-39.
2. Son JY, et al. Mol Cancer Ther. 2014 Jul; 13 (7):1704-16.
3. Yoon JH, et al. EMBO Mol Med. 2013 Nov; 5 (11):1720-39.
Similar Products
Product Notes
The EW-7197 (Catalog #AAA3601430) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "EW-7197, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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