Structure
LFM-A13, Inhibitor
LFM-A13
Purity
>98% (HPLC)
Synonyms
LFM-A13; LFM A13; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=42mg/mL
Target
BTK
Receptor
BTK
Chemical Name
2-Butenamide, 2-cyano-N-(2, 5-dibromophenyl)-3-hydroxy-, (2Z)
SMILES
C/C(O)=C(C#N)/C(NC1=CC(Br)=CC=C1Br)=O
Molecular Formula
C11H8Br2N2O2
CAS Number
244240-24-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for LFM-A13, inhibitor
A highly specific inhibitor of BTK with Ki of 1.4uM, IC50 of 17.2uM; shows no activity against EGFR, IRK, JAK1, JAK3, or HCK; enhances the sensitivity to ceramide- or vincristine-induced apoptosis in BTK+ B-lineage leukemic cells; prolongs the median survival time of VPL-treated mice; also inhibits Plk3 with IC50 of 61uM, prevented bipolar mitotic spindle assembly in human breast cancer cells and glioblastoma cells, delays tumor progression in MMTV/neu transgenic mouse model of HER2 positive breast cancer.
Product Categories/Family for LFM-A13, inhibitor
References
1. Mahajan S, et al. J Biol Chem. 1999 Apr 2; 274 (14):9587-99.
2. Uckun FM, et al. Bioorg Med Chem. 2007 Jan 15; 15 (2):800-14.
3. Uckun FM, et al. Clin Cancer Res. 2002 May; 8 (5):1224-33.
2. Uckun FM, et al. Bioorg Med Chem. 2007 Jan 15; 15 (2):800-14.
3. Uckun FM, et al. Clin Cancer Res. 2002 May; 8 (5):1224-33.
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Product Notes
The LFM-A13 (Catalog #AAA3603705) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "LFM-A13, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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