Structure
QL-47, Inhibitor
QL-47
Purity
>98% (HPLC)
Synonyms
QL-47; QL47; QL 47; QL47. QL-XII-47; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: <9.4mg/mL
Target
BTK
Receptor
BTK
Chemical Name
Benzo[h]-1, 6-naphthyridin-2(1H)-one, 1-[2, 3-dihydro-1-(1-oxo-2-propen-1-yl)-1H-indol-6-yl]-9-(1-methyl-1H-pyrazol-4-yl)
SMILES
O=C1N(C2=CC3=C(C=C2)CCN3C(C=C)=O)C4=C(C=NC5=CC=C(C6=CN(C)N=C6)C=C54)C=C1
Molecular Formula
C27H21N5O2
CAS Number
1469988-75-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for QL-47, inhibitor
A potent, selective, and irreversible BTK inhibitor with IC50 of 7nM; inhibits BTK kinase activity with an IC50 of 7nM, inhibits autophosphorylation of BTK on Tyr223 in cells with an EC50 of 475nM, and inhibits phosphorylation of a downstream effector PLCgamma2 (Tyr759) with an EC50 of 318nM; induces a G1 cell cycle arrest that is associated with pronounced degradation of BTK protein in Ramos cells; inhibits the proliferation of B-cell lymphoma cancer cell lines at submicromolar concentrations. Blood Cancer Preclinical
Product Categories/Family for QL-47, inhibitor
References
1. Wu H, et al. ACS Chem Biol. 2014 May 16; 9 (5):1086-91.
2. Liang Y, et al. ACS Med Chem Lett. 2017 Feb 3; 8 (3):344-349.
3. Wang B, et al. Eur J Med Chem. 2017 Sep 8; 137:545-557.
2. Liang Y, et al. ACS Med Chem Lett. 2017 Feb 3; 8 (3):344-349.
3. Wang B, et al. Eur J Med Chem. 2017 Sep 8; 137:545-557.
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Product Notes
The QL-47 (Catalog #AAA3602013) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "QL-47, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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