Structure
BMX-IN-1, Inhibitor
BMX-IN-1
Purity
>98% (HPLC)
Synonyms
BMX-IN-1; BMX kinase inhibitor; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
BMX Kinase
Receptor
BMX Kinase
Chemical Name
2-Propenamide, N-[2-methyl-5-[9-[4-[(methylsulfonyl)amino]phenyl]-2-oxobenzo[h]-1, 6-naphthyridin-1(2H)-yl]phenyl]
SMILES
C=CC(NC1=CC(N2C(C=CC3=C2C4=CC(C5=CC=C(NS(=O)(C)=O)C=C5)=CC=C4N=C3)=O)=CC=C1C)=O
Molecular Formula
C29H24N4O4S
CAS Number
1431525-23-3
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for BMX-IN-1, inhibitor
BMX-IN-1 (CAS 1431525-23-3) is a potent, selective, irreversible inhibitor of BMX kinase with IC50 of 8nM; also inhibits BTK with IC50 of 10.4nM and displays 47-656-fold less potent for Blk, JAK3, EGFR, Itk, or Tec; inhibits the proliferation of Tel-BMX-transformed Ba/F3 prostate cancer cells with GI50 of 25nM, exhibits antiproliferative activity in RV-1, DU-145, PC-3, and VCAP prostate cancer cell lines with GI50 of 2-5uM. Prostate cancer Preclinical
Product Categories/Family for BMX-IN-1, inhibitor
References
1. Liu F, et al. ACS Chem Biol. 2013 Jul 19; 8 (7):1423-8.
Similar Products
Product Notes
The BMX-IN-1 (Catalog #AAA3601829) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BMX-IN-1, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
