Testing Data
Zoledronic Acid, Inhibitor
Zoledronic Acid (Zoledronate)
Synonyms
Zoledronic Acid; Zoledronic Acid (Zoledronate); inhibitor
Solubility
DMSO <1 mg/mL - Water >=4 mg/mL - Ethanol <1 mg/mL
Formula
C5H10N2O7P2
CAS Number
118072-93-8
Preparation and Storage
Stable for; 2 years at -20 degree C Powder
1 week -4 degree C in DMSO
1 month -80 degree C in DMSO
1 week -4 degree C in DMSO
1 month -80 degree C in DMSO
Testing Data
Testing Data
Related Product Information for Zoledronic Acid, inhibitor
Zoledronic acid, one of the most potent nitrogen-containing BPs(bisphosphonates), induces antiproliferative and apoptotic effects on multiple myeloma cell lines in vitro, by activating protein kinase C, and increases the extracellular calcium concentration. Zoledronic acid and radiation caused a dosedependent and time-dependent decrease in cell viability (approximate 50% growth inhibition values were 48 muM and 20muM for 24 hours and 72 hours, respectively, for zoledronic acid and 500 cGy for radiation). [1] Zoledronate is also known as zometa. It is a treatment for hypercalcemia (high levels of calcium in the blood) caused by tumors. Tumor-induced hypercalcemia is also known as hyper-calcemia of malignancy (HCM). [2] Zoledronic acid also inhibited proliferation of human foetal osteoblastic cell line (hFOB) with an IC50 of 40 muM. In cultures of freshly isolated rabbit and human osteoclasts zoledronic acid (10-100 muM) induced morphological features similar to apoptosis and caspase-3-like activation. Osteoclastogenesis was inhibited in a dose-dependent manner with an IC50 of 15 nM in vitro in cultures of murine bone marrow cells stimulated to form osteoclasts by addition of macrophage-colony stimulating factor and ligand for the receptor activator NF-kappaB (RANKL).
Product Categories/Family for Zoledronic Acid, inhibitor
Similar Products
Product Notes
The Zoledronic Acid (Catalog #AAA8506406) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Zoledronic Acid, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
