Testing Data
Erlotinib Hydrochloride, Inhibitor
Erlotinib Hydrochloride (Tarceva)
Purity
>99%
Synonyms
Erlotinib Hydrochloride; Erlotinib Hydrochloride (Tarceva); inhibitor
Purity/Purification
>99%
Solubility
DMSO >=3mg/mL - Water <1mg/mL - Ethanol <1mg/mL
Formula
C22H23N3O4.HCl
CAS Number
183319-69-9
Preparation and Storage
Store at-20 degree C 2 years.
Testing Data
Testing Data
Related Product Information for Erlotinib Hydrochloride, inhibitor
Preclinical studies have shown that very low concentrations are required to inhibit activity against isolated tyrosine kinase(IC50, 2 nmol/L), to reduce HER1/EGFR autophosphorylation in intact human tumor cells in vitro (IC50, 20 nmol/L), and to inhibit the EGF-dependent proliferation of cells (10). It acts by inducing the expression of the cell-cycle inhibitor p27, and suppressing the expression of the cell-cycle promoter cyclin D1, thereby blocking cell-cycle progression at the G1 phase [1]. Assessment of the effect of various oral doses of erlotinib on tumor growth in the HN5 head and neck tumor xenograft model indicated a marked improvement in antitumor effect between doses of 1.6 and 12.5 mg/kg; since the 12.5 mg/kg dose resulted in no substantive tumor growth, relative improvements in antitumor effect at higher doses are not readily apparent. [2]
Product Categories/Family for Erlotinib Hydrochloride, inhibitor
References
Induction of Apoptosis and Cell Cycle Arrest by CP-358, 774, an Inhibitor of Epidermal Growth Factor Receptor Tyrosine Kinase Moyer JD, et al. Cancer Res. 1997; 57:4838-48 MANUEL HIDALGO, et al. ONCOLOGY; Vol. 17 No. 11 12 The pharmacological and toxicological properties of this product have not been fully investigated. Exercise caution in use and handling. This product must not be used in humans.
Similar Products
Product Notes
The Erlotinib Hydrochloride (Catalog #AAA8506454) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Erlotinib Hydrochloride, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
