Structure
GSK2578215A, Inhibitor
GSK2578215A
Purity
>98% (HPLC)
Synonyms
GSK2578215A; GSK-2578215A; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
LRRK2
Receptor
LRRK2 (G2019S); LRRK2 (WT)
Chemical Name
Benzamide, 5-(2-fluoro-4-pyridinyl)-2-(phenylmethoxy)-N-3-pyridinyl
SMILES
O=C(NC1=CC=CN=C1)C2=CC(C3=CC(F)=NC=C3)=CC=C2OCC4=CC=CC=C4
Molecular Formula
C24H18FN3O2
CAS Number
1285515-21-0
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for GSK2578215A, inhibitor
GSK2578215A is a highly potent, selective, BBB-permeable LRRK2 inhibitor with IC50 of 10.9 and 9.9nM for wild-type LRRK2 and the G2019S mutant, respectively; shows 8-fold reduced potentcy against A2016T mutant LRRK2 (IC50=81nM); inhibits Ser910 and Ser935 phosphorylation in both wild-type LRRK2 and LRRK2 G2019S stably transfected into HEK293 cells at 0.1-0.3uM, also induces dephosphorylation of Ser910 and 935 at 1-3uM in the inhibitor-resistant LRRK2 [A2016T+ G2019S] and LRRK2 [A2016T] mutants; induces protective autophagy in SH-SY5Y cells.
Product Categories/Family for GSK2578215A, inhibitor
References
1. Reith AD, et al. Bioorg Med Chem Lett. 2012 Sep 1; 22 (17):5625-9.
2. Saez-Atienzar S, et al. Cell Death Dis. 2014 Aug 14; 5:e1368.
2. Saez-Atienzar S, et al. Cell Death Dis. 2014 Aug 14; 5:e1368.
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Product Notes
The GSK2578215A (Catalog #AAA3601166) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "GSK2578215A, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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