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Structure

AK-7, Inhibitor

AK-7

Purity
>98% (HPLC)
Synonyms
AK-7; AK 7; AK7; inhibitor
Ordering
 
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For Research Use Only!
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
Sirtuin
Receptor
Sirtuin
Chemical Name
Benzamide, N-(3-bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]
SMILES
O=C(NC1=CC=CC(Br)=C1)C2=CC=CC(S(=O)(N3CCCCCC3)=O)=C2
Molecular Formula
C19H21BrN2O3S
CAS Number
420831-40-9
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack

Structure

Related Product Information for AK-7, inhibitor
A potent, selective and brain-permeable SIRT2 inhibitor with IC50 of 15.5uM; reduces cholesterol in cultured naive neuronal cells and brain slices from wild-type mice; shows neuroprotective activity in Huntington's disease mouse models, and reduces cholesterol in neuronal models.
Product Categories/Family for AK-7, inhibitor
References
1. Taylor DM, et al. ACS Chem Biol. 2011 Jun 17; 6 (6):540-6.
2. Chopra V, et al. Cell Rep. 2012 Dec 27; 2 (6):1492-7.
3. Biella G, et al. J Alzheimers Dis. 2016 Jun 30; 53 (3):1193-207.

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Product Notes

The AK-7 (Catalog #AAA3604433) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "AK-7, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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