Structure
MLi-2, Inhibitor
MLi-2
Purity
>98% (HPLC)
Synonyms
MLi-2; MLi2; Mli 2; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=26mg/mL
Target
LRRK2
Receptor
LRRK2
Chemical Name
1H-Indazole, 3-[6-[(2R, 6S)-2, 6-dimethyl-4-morpholinyl]-4-pyrimidinyl]-5-[(1-methylcyclopropyl)oxy]-, rel
SMILES
CC1(OC2=CC3=C(NN=C3C4=CC(N5C[C@H](C)O[C@H](C)C5)=NC=N4)C=C2)CC1
Molecular Formula
C21H25N5O2
CAS Number
1627091-47-7
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for MLi-2, inhibitor
A potent, selective, orally available and brain-penetrant LRRK2 inhibitor with kinase IC50 of 0.76nM, cellular IC50 of 1.4nM (dephosphorylation of LRRK2 pSer935 LRRK2); displays >295-fold selectivity for over 300 kinases in addition to a diverse panel of receptors and ion channels; signficantly reduces the ratio of phosphorylated Ser935 LRRK2 (pS935) to total LRRK2 in the mouse cortex, consistent with enlarged type II pneumocytes.
Product Categories/Family for MLi-2, inhibitor
References
1. Scott JD, et al. J Med Chem. 2017 Apr 13; 60 (7):2983-2992.
2. Fell MJ, et al. J Pharmacol Exp Ther. 2015 Dec; 355 (3):397-409.
3. Volpicelli-Daley LA, et al. J Neurosci. 2016 Jul 13; 36 (28):7415-27.
2. Fell MJ, et al. J Pharmacol Exp Ther. 2015 Dec; 355 (3):397-409.
3. Volpicelli-Daley LA, et al. J Neurosci. 2016 Jul 13; 36 (28):7415-27.
Similar Products
Product Notes
The MLi-2 (Catalog #AAA3602407) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MLi-2, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
