Structure
CK-37, Inhibitor
CK-37
Purity
>98% (HPLC)
Synonyms
CK-37; ChoK-alpha inhibitor CK37; inhibitor
Purity/Purification
>98% (HPLC)
Target
ChoK
Receptor
ChoK
Chemical Name
N-(3, 5-dimethylphenyl)-2-[[5-(4-ethylphenyl)-1H-1, 2, 4-triazol-3-yl]sulfanyl] acetamide
SMILES
CCC1=CC=C(C=C1)C2=NC(=NN2)SCC(=O)NC3=CC(=CC(=C3)C)C
Molecular Formula
C20H22N4OS
CAS Number
1001478-90-5
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for CK-37, inhibitor
A potent, specific, competitive inhibitor of choline kinase-alpha (Chok-alpha) by targeting the choline binding site; significantly increases LC3II expression in MCF-7 and MCF-7/TAM cells, increases the size and number of autophagosome, causes MCF-7 and MCF-7/TAM cells to a slight increase in p62; suppresses MAPK and PI3K/AKT signaling, disrupts actin cytoskeletal organization, and reduces plasma membrane ruffling; significantly decreases tumor growth in a lung tumor xenograft mouse model, suppresses tumor phosphocholine, and diminishes activating phosphorylations of ERK and AKT in vivo.
Product Categories/Family for CK-37, inhibitor
References
1. Clem BF, et al. Oncogene. 2011 Jul 28; 30 (30):3370-80.
2. Kim HS, et al. PLoS One. 2015 Oct 23; 10 (10):e0141110.
3. Wong MT, et al. J Virol. 2016 Sep 29; 90 (20):9075-95.
2. Kim HS, et al. PLoS One. 2015 Oct 23; 10 (10):e0141110.
3. Wong MT, et al. J Virol. 2016 Sep 29; 90 (20):9075-95.
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Product Notes
The CK-37 (Catalog #AAA3600017) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "CK-37, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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