Structure
Z-360 Biochemical
Z-360
Purity
>98% (HPLC)
Synonyms
Z-360; Nastorazepide; Z-360 biochemical
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=32mg/mL
Target
Cholecystokinin Receptor
Receptor
Cholecystokinin Receptor
Chemical Name
Benzoic acid, 3-[[[[(3R)-5-cyclohexyl-1-(3, 3-dimethyl-2-oxobutyl)-2, 3, 4, 5-tetrahydro-2-oxo-1H-1, 5-benzodiazepin-3-yl]amino]carbonyl]amino]
SMILES
O=C(O)C1=CC=CC(NC(N[C@@H]2CN(C3CCCCC3)C4=CC=CC=C4N(CC(C(C)(C)C)=O)C2=O)=O)=C1
Molecular Formula
C29H36N4O5
CAS Number
209219-38-5
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Z-360 biochemical
A novel potent, orally active CCK-2/gastrin receptor antagonist with Ki of 0.47nM; significantly reduces gastrin-induced PKB/Akt phosphorylation in human CCK-2 receptor-expressing cells; significantly inhibits the growth of MiaPaCa2, also suppresses pancreatic tumor growth and prolong survival in a pancreatic carcinoma xenograft model combined with gemcitabine; prevents up-regulation of ephrin B1 gene expression and phosphorylation of NR2B via suppression of interleukin-1 beta production in a cancer-induced pain model in mice. Pancreatic Cancer Phase 2 Clinical
Product Categories/Family for Z-360 biochemical
References
1. Kawasaki D, et al. Cancer Chemother Pharmacol. 2008 Apr; 61 (5):883-92.
2. Meyer T, et al. Eur J Cancer. 2010 Feb; 46 (3):526-33.
3. Orikawa Y, et al. Mol Pain. 2010 Oct 28; 6:72.
2. Meyer T, et al. Eur J Cancer. 2010 Feb; 46 (3):526-33.
3. Orikawa Y, et al. Mol Pain. 2010 Oct 28; 6:72.
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Product Notes
The Z-360 (Catalog #AAA3603278) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Z-360, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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