Structure
MI-2, Inhibitor
MI-2
Purity
>98% (HPLC)
Synonyms
MI-2; MI 2; MI2; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=46mg/mL
Target
MALT1
Receptor
MALT1
Chemical Name
Acetamide, 2-chloro-N-[4-[5-(3, 4-dichlorophenyl)-3-(2-methoxyethoxy)-1H-1, 2, 4-triazol-1-yl]phenyl]
SMILES
O=C(NC1=CC=C(N2N=C(OCCOC)N=C2C3=CC=C(Cl)C(Cl)=C3)C=C1)CCl
Molecular Formula
C19H17Cl3N4O3
CAS Number
1047953-91-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for MI-2, inhibitor
MI-2 (MALT1 inhibitor) is a selective, irreversible MALT1 paracaspase inhibitor with IC50 of 5.84uM, displays little activity against the related caspase family members caspase-3, -8, and -9; inhibits cleavage of MALT1 substrates, which is accompanied by NF-kappaB reporter activity suppression, c-REL nuclear localization inhibition, and NF-kappaB target gene downregulation; specifically suppress ABC-DLBCL in vitro and in vivo, exhibits GI 50 of 0.2, 0.5, 0.4, and 0.4uM for HBL-1, TMD8, OCI-Ly3, and OCI-Ly10 cells respectively, inhibits nuclear translocation of RelB and p50, and decreases Bcl-xL levels in CLL cells.
Product Categories/Family for MI-2, inhibitor
References
1. Fontan L, et al. Cancer Cell. 2012 Dec 11; 22 (6):812-24.
2. Saba NS, et al. Cancer Res. 2017 Dec 15; 77 (24):7038-7048.
3. Liu W, et al. Oncotarget. 2016 May 24; 7 (21):30536-49.
4. Yeh CN, et al. Oncotarget. 2017 Dec 8; 8 (69):113444-113459.
2. Saba NS, et al. Cancer Res. 2017 Dec 15; 77 (24):7038-7048.
3. Liu W, et al. Oncotarget. 2016 May 24; 7 (21):30536-49.
4. Yeh CN, et al. Oncotarget. 2017 Dec 8; 8 (69):113444-113459.
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Product Notes
The MI-2 (Catalog #AAA3600236) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "MI-2, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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