Testing Data
BIX-01294 3HCl, Inhibitor | BIX-01294, inhibitor
BIX-01294 3HCl
Purity
>98%
Synonyms
BIX-01294 3HCl; 2-(Hexahydro-4-methyl-1H-1; 4-diazepin-1-yl)-6; 7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine trihydrochloride; BIX-01294; inhibitor
Purity/Purification
>98%
Specific Activity
Histone Methyl Transferase Inhibitor
CAS Registry Number
935693-62-2
Molecular Formula
C28H38N6O2.3HCl
Solubility
May be dissolved in water (50mg/ml) or DMSO (50mg/ml)
Preparation and Storage
Store desiccated as supplied at ambient for up to 2 years. Store solutions at -20 degree C for up to 3 months.
Testing Data
Testing Data
Related Product Information for BIX-01294, inhibitor
BIX-01294 is a selective inhibitor of G9a histone methyltransferase (G9aHMTase; IC50 = 1.7 uM) as well as GLP HMTase (IC50 = 38 uM) leading to a decrease in H3K9Me2 (histone H3 lysine 9 methylation) in vitro1. It facilitates the reactivation of pluripotency genes and induces passive demethylation, thus promoting reprogramming2. BIX-01294, in combination with BAY K8644 (a calcium channel agonist), was found to improve reprogramming efficiencies of Oct4-Klf4-(OK)-infected neural progenitor cells3. It induced apoptosis and decreased proliferation, mobility and invasion in human neuroblastoma cells4.
Product Categories/Family for BIX-01294, inhibitor
References
1. S Kubicek et al. Mol. Cell 2007 25:473
2. D Huangfu et al. Nat. Biotechnol. 2008 26:795
3. Y Shi et al. Cell Stem Cell 2008 2:525
4. Z Lu et al. Anticancer Drugs 2013 24:484
2. D Huangfu et al. Nat. Biotechnol. 2008 26:795
3. Y Shi et al. Cell Stem Cell 2008 2:525
4. Z Lu et al. Anticancer Drugs 2013 24:484
Similar Products
Product Notes
The BIX-01294 (Catalog #AAA516414) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BIX-01294 3HCl, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
