Testing Data
UNC1999, Inhibitor
UNC1999
Purity
>98% (HPLC)
Synonyms
UNC1999; N-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-1-propan-2-yl-6-[6-(4-propan-2-ylpiperazin-1-yl)pyridin-3-yl]indazole-4-carboxamide; inhibitor
Purity/Purification
>98% (HPLC)
Specific Activity
Methyltransferase Inhibitor
CAS Registry Number
1431612-23-5
Molecular Formula
C33H43N7O2
Solubility
May be dissolved in DMSO (10mg/ml)
Preparation and Storage
Store desiccated at -20 degree C. Store solutions at -20 degree C for 3 months.
Testing Data
Testing Data
Related Product Information for UNC1999, inhibitor
UNC1999 is an orally active, highly selective inhibitor of both wild-type and mutant EZH1 and EZH2 lysine methyltransferases (IC50 = 45 nM and 2 nM respectively)1. Inhibition of EZH2 with UNC1999 enhanced the efficacy of gefitinib in suppressing the proliferation of colon cancer cells2. It suppresses global H3K27 trimethylation/demethylation and inhibits the growth of mixed lineage leukemia (MLL)-rearranged leukemia cells3.
Product Categories/Family for UNC1999, inhibitor
References
1. KD Konze et al. ACS Chem. Biol. 2013 8:1324
2. BW Katona et al. Cancer Biol. Ther. 2014 15:1677
3. B Xu et al. Blood 2015 125:346
2. BW Katona et al. Cancer Biol. Ther. 2014 15:1677
3. B Xu et al. Blood 2015 125:346
Similar Products
Product Notes
The UNC1999 (Catalog #AAA516367) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "UNC1999, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
