Structure
BC-1215, Inhibitor
BC-1215
Purity
>98% (HPLC)
Synonyms
BC-1215; BC 1215; BC1215; inhibitor
Purity/Purification
>98% (HPLC)
Target
E3 Ubiquitin Ligase
Receptor
E3 Ubiquitin Ligase
Chemical Name
N1, N2-bis(4-(pyridin-2-yl)benzyl)ethane-1, 2-diamine
SMILES
C1=CC=NC(=C1)C2=CC=C(C=C2)CNCCNCC3=CC=C(C=C3)C4=CC=CC=N4
Molecular Formula
C26H26N4
CAS Number
1507370-20-8
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for BC-1215, inhibitor
BC-1215 (BC1215) is a potent, highly unique, selective E3 ligase F box component Fbxo3 inhibitor with IL1beta IC50 of 0.9ug/mL; inhibits the Fbxo3-TRAF activation pathway for cytokine release, increases immunoreactive Fbxl2 levels and reduces TRAF proteins, impairs Fbxo3 ubiquitination of Fbxl2 with IC50 of 0.1uM in vitro ubiquitination assay; reversibly inhibits Fbxo3 to destabilize TRAF proteins, remarkably suppresses the majority of the Th1 panel cytokines including G-CSF, GM-CSF, GROalpha, I-309, IL1-alpha, IL1-beta, IL1ralpha, IL-6, IL-12, IL-23, MIP-1alpha, MIP-1beta and TNFalpha, in PBMCs; ameliorates the severity of viral pneumonia, septic shock, colitis, and cytokine-driven inflammation systemically in murine models. Solid Tumors Phase 1 Clinical
Product Categories/Family for BC-1215, inhibitor
References
1. Mallampalli RK, et al. J Immunol. 2013 Nov 15; 191 (10):5247-55.
2. Lin TB, et al. J Neurosci. 2015 Dec 16; 35 (50):16545-60.
3. Lai CY, et al. J Neurosci. 2016 Sep 14; 36 (37):9722-38.
4.Chen BB, et al. Nat Immunol. 2013 May; 14 (5):470-9.
2. Lin TB, et al. J Neurosci. 2015 Dec 16; 35 (50):16545-60.
3. Lai CY, et al. J Neurosci. 2016 Sep 14; 36 (37):9722-38.
4.Chen BB, et al. Nat Immunol. 2013 May; 14 (5):470-9.
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Product Notes
The BC-1215 (Catalog #AAA3602103) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BC-1215, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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