NCBI and Uniprot Product Information
NCBI Description
This gene encodes the final component of the complement system. It participates in the formation of the Membrane Attack Complex (MAC). The MAC assembles on bacterial membranes to form a pore, permitting disruption of bacterial membrane organization. Mutations in this gene cause component C9 deficiency. [provided by RefSeq, Feb 2009]
Uniprot Description
C9: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C9 is the pore-forming subunit of the MAC. Defects in C9 are a cause of complement component 9 deficiency (C9D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Extracellular matrix; Apoptosis
Chromosomal Location of Human Ortholog: 5p14-p12
Cellular Component: membrane attack complex; integral to plasma membrane; cytoplasm; extracellular region; plasma membrane
Biological Process: complement activation, alternative pathway; regulation of complement activation; innate immune response; hemolysis by symbiont of host red blood cells; complement activation, classical pathway
Disease: Macular Degeneration, Age-related, 15; Complement Component 9 Deficiency
Research Articles on C9
Similar Products
Product Notes
The Rat C9 c9 (Catalog #AAA721706) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA721706 ELISA Kit recognizes Rat C9. It is sometimes possible for the material contained within the vial of "Complement Component 9, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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