Structure
BC-23, Inhibitor
BC-23
Purity
>98% (HPLC)
Synonyms
BC-23; BC23; NSC 45382; inhibitor
Purity/Purification
>98% (HPLC)
Target
Beta-catenin
Receptor
Beta-catenin
Chemical Name
4-[(3-chloro-1, 4-dioxonaphthalen-2-yl)amino]-N-pyridin-2-ylbenzenesulfonamide
SMILES
O=S(C1=CC=C(NC(C2=O)=C(Cl)C(C3=C2C=CC=C3)=O)C=C1)(NC4=NC=CC=C4)=O
Molecular Formula
C21H14ClN3O4S
CAS Number
6298-15-3
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for BC-23, inhibitor
BC-23 (NSC 45382) is a novel inhibitor of beta-catenin/Tcf4 interaction with IC50 of 1.7uM; dose-dependently inhibits TOP-luciferase activity in H1299 cells with IC50 of 2.3uM; causes strong synergistic enhancement of the cancer cell death induced by low doses of radiation; effectively inhibits Wnt/beta-catenin signaling and down-regulates c-Myc and cyclin D1 expression, induces S phase and ROS generation, and overcomes radioresistance in human NSCLC cells.
Product Categories/Family for BC-23, inhibitor
References
1. Zhang Q, et al. PLoS One. 2016 Mar 25; 11 (3):e0152407.
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Product Notes
The BC-23 (Catalog #AAA3605379) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BC-23, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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