Structure
AG-1295, Inhibitor
AG-1295
Purity
>98% (HPLC)
Synonyms
AG-1295; NSC 380341; Tyrphostin AG 1295; inhibitor
Purity/Purification
>98% (HPLC)
Target
PDGFR
Receptor
PDGFR
Chemical Name
6, 7-dimethyl-2-phenyl-quinoxaline
SMILES
CC1=C(C)C=C2N=CC(C3=CC=CC=C3)=NC2=C1
Molecular Formula
C16H14N2
CAS Number
71897-07-9
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for AG-1295, inhibitor
A quinoxaline-type tyrphostin that acts as a potent and selective inhibitor of PDGFR kinase in vitro and in Swiss 3T3 cells with IC50 of 0.3-1uM; inhibits PDGF-stimulated DNA synthesis with IC50 of 2.5uM without affecting activity of EGFR; selectively attenuates smooth muscle cell growth in vitro and reduces neointimal formation after balloon angioplasty in swine. Blood Cancer Discontinued
Product Categories/Family for AG-1295, inhibitor
References
1. Kovalenko M, et al. Cancer Res. 1994 Dec 1; 54 (23):6106-14.
2. Banai S, et al. Circulation. 1998 May 19; 97 (19):1960-9.
3. Iwamoto H, et al. J Lab Clin Med. 2000 May; 135 (5):406-12.
4. Karck M, et al. Transplantation. 2002 Nov 15; 74 (9):1335-41.
2. Banai S, et al. Circulation. 1998 May 19; 97 (19):1960-9.
3. Iwamoto H, et al. J Lab Clin Med. 2000 May; 135 (5):406-12.
4. Karck M, et al. Transplantation. 2002 Nov 15; 74 (9):1335-41.
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Product Notes
The AG-1295 (Catalog #AAA3605748) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "AG-1295, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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