Structure
ASP3026, Inhibitor
ASP3026
Purity
>98% (HPLC)
Synonyms
ASP3026; ASP 3026; ASP-3026; inhibitor
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
ALK
Receptor
ALK
Chemical Name
1, 3, 5-Triazine-2, 4-diamine, N2-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]
SMILES
O=S(C1=CC=CC=C1NC2=NC=NC(NC3=CC=C(N4CCC(N5CCN(C)CC5)CC4)C=C3OC)=N2)(C(C)C)=O
Molecular Formula
C29H40N8O3S
CAS Number
1097917-15-1
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for ASP3026, inhibitor
ASP3026 is a potent small molecule ALK inhibitor with IC50 of 3.5, 10, 5.4 and 6.8nM for wt ALK, ALK F1174L, ALK R1275Q and NPM1-ALK, respectively; also potently inhibits Ack, EGFR L858R, FRK and LTK with IC50 of 5-85nM, inhibits the growth of NCI-H2228 cells with IC50 of 64.8nM; enhances the antitumor activities of paclitaxel and pemetrexed without affecting body weight in mice model. Blood Cancer Phase 1 Discontinued
Product Categories/Family for ASP3026, inhibitor
References
1. Mori M, et al. Mol Cancer Ther. 2014 Feb; 13 (2):329-40.
2. George SK, et al. Oncotarget. 2014 Jul 30; 5 (14):5750-63.
3. Mologni L, et al. Oncotarget. 2015 Mar 20; 6 (8):5720-34.
4. Iikubo K, et al. Chem Pharm Bull (Tokyo). 2018; 66 (3):251-262.
2. George SK, et al. Oncotarget. 2014 Jul 30; 5 (14):5750-63.
3. Mologni L, et al. Oncotarget. 2015 Mar 20; 6 (8):5720-34.
4. Iikubo K, et al. Chem Pharm Bull (Tokyo). 2018; 66 (3):251-262.
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Product Notes
The ASP3026 (Catalog #AAA3600377) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "ASP3026, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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