IL5RA recombinant protein

Human IL5RA Protein, hFc Tag

Cat. Num. AAA188284

• Gene Names: IL5RA; IL5R; CD125; CDw125; HSIL5R3
• Purity: >90%. Affinity purification
• Synonyms: IL5RA; Human IL5RA Protein; hFc Tag; IL5Ra; CD125; IL-5 R alpha; IL5RA recombinant protein

• Host: HEK293 cells
• Purity/Purification: >90%. Affinity purification
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose is added as protectants before lyophilization.
• Sequence: IL5RA (Asp21-Pro338) + hFc (Glu99-Ala330)

• Origin: Human
• Reconstitution: Reconstitute with deionized water
• Tag: C-Human Fc tag
• Preparation and Storage: Store at -80 degree C for 12 months (Avoid repeated freezing and thawing)

SDS-Page

(Figure 1. Human IL5RA Protein, hFc Tag on SDS-PAGE under reducing condition.)

Related Product Information for IL5RA recombinant protein

The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported.

NCBI and Uniprot Product Information

• NCBI GI #: 191175130
• NCBI GeneID: 3568
• UniProt Accession #: Q01344; Q14633; Q15469; Q6ISX9; B3IU77; B4E2G0
• Molecular Weight: 47,685 Da
• NCBI Official Full Name: interleukin 5 receptor alpha transcript variant 7
• NCBI Official Synonym Full Names: interleukin 5 receptor, alpha
• NCBI Official Symbol: IL5RA
• NCBI Official Synonym Symbols: IL5R; CD125; CDw125; HSIL5R3
• NCBI Protein Information: interleukin-5 receptor subunit alpha; CD125 antigen; IL-5R subunit alpha; IL-5 receptor subunit alpha; interleukin 5 receptor type 3; interleukin-5 receptor alpha chain
• UniProt Protein Name: Interleukin-5 receptor subunit alpha
• Protein Family: Interleukin-5 receptor
• UniProt Gene Name: IL5RA
• UniProt Synonym Gene Names: IL5R; IL-5 receptor subunit alpha; IL-5R subunit alpha; IL-5R-alpha; IL-5RA
• UniProt Entry Name: IL5RA_HUMAN

NCBI Description

The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported. [provided by RefSeq, Jul 2011]

Uniprot Description

IL5RA: This is the receptor for interleukin-5. The alpha chain binds to IL5. Belongs to the type I cytokine receptor family. Type 5 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 3p26-p24

Cellular Component: extracellular space; plasma membrane; integral to membrane

Molecular Function: protein binding; interleukin-5 receptor activity

Biological Process: cell proliferation; regulation of interleukin-5 production; inflammatory response to antigenic stimulus; signal transduction