Hemopexin Native Protein | HPX native protein

Human Hemopexin

Cat. Num. AAA143111

• Gene Names: HPX; HX
• Purity: Greater than 95.0%.
• Synonyms: Hemopexin; Human Hemopexin; Hemopexin Human; Beta-1B-glycoprotein; HPX; Haemopexin; HPX native protein

• Host: Human Plasma
• Purity/Purification: Greater than 95.0%.
• Form/Format: Lyophilized from (1.22mg/ml) solution containing 11.9mM phosphate buffer, 137mM NaCl and 2.7mM KCl, pH 7.4.; Sterile Filtered White lyophilized (freeze-dried) powder.
• Sequence Length: 462

• Solubility: It is recommended to reconstitute the lyophilized Hemopexin in phosphate buffer, pH >7.0 containing 0.15M NaCl.
• Human Virus Test: Serum from each donor has been tested and found negative for antibody to HIV-1, HIV-2, HCV, HBSAG.
• Preparation and Storage: Human Hemopexin although stable at room temperature for 2 weeks, should be stored at -20 degree C.

Related Product Information for HPX native protein

Description: Human Hemopexin produced in Human plasma having a molecular mass of 70 kDa.

Introduction: Hemopexin (or haemopexin) is a plasma protein that binds heme with the highest affinity of any known protein. Hemopexin is generally expressed in liver, and belongs to acute phase reactants, the synthesis of which is induced after inflammation. Heme is potentially very toxic because of its ability to intercalate into lipid membrane and to generate hydroxyl radicals. Hemopexin's function of scavenging the heme released or lost by the turnover of heme proteins such as hemoglobin defends the body from the oxidative damage that free heme can cause. Additionally, hemopexin discharges its bound ligand for internalisation upon interacting with a specific receptor located on the surface of liver cells. This hemopexin function is in order to preserve the body's iron. Hemopexin's levels in the serum are an indication of how much heme is present in the blood. Low Hemopexin levels show that there is a lot of it in the serum. For that reason, low hemopexin levels indicate that there has been considerable degradation of heme containing compounds - mainly hemoglobin, it indicates hemolysis and low hemopexin levels are therefore one of the features of a hemolytic anemia. It's a Haem binding protein used in the assessment of intravascular haemolysis in conjunction with haptoglobin.

Product Categories/Family for HPX native protein

Recombinant & Natural Proteins; Natural Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 11321561
• NCBI GeneID: 3263
• NCBI Accession #: NP_000604.1
• NCBI GenBank Nucleotide #: NM_000613.2
• UniProt Accession #: P02790; B2R957
• Molecular Weight: 51,676 Da
• NCBI Official Full Name: hemopexin
• NCBI Official Synonym Full Names: hemopexin
• NCBI Official Symbol: HPX
• NCBI Official Synonym Symbols: HX
• NCBI Protein Information: hemopexin; beta-1B-glycoprotein
• UniProt Protein Name: Hemopexin
• Protein Family: Hemopexin
• UniProt Gene Name: HPX
• UniProt Entry Name: HEMO_HUMAN

NCBI Description

This gene encodes a plasma glycoprotein that binds heme with high affinity. The encoded protein is an acute phase protein that transports heme from the plasma to the liver and may be involved in protecting cells from oxidative stress. [provided by RefSeq, Apr 2009]

Uniprot Description

HPX: Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. Belongs to the hemopexin family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 11p15.5-p15.4

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; metal ion binding; heme transporter activity

Biological Process: positive regulation of humoral immune response mediated by circulating immunoglobulin; receptor-mediated endocytosis; heme transport; positive regulation of tyrosine phosphorylation of Stat1 protein; positive regulation of immunoglobulin production; viral reproduction; hemoglobin metabolic process; cellular iron ion homeostasis; heme metabolic process