Typical Testing Data/Standard Curve (for reference only)
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Human Protein Wnt-10b (WNT10B) ELISA Kit | WNT10B elisa kit
Human Protein Wnt-10b (WNT10B) ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
()
Typical Testing Data/Standard Curve (for reference only)
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Background/Introduction: WNT10B is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region. The human WNT10B sequence is 88% and 95% identical to the mouse gene at nucleotide and amino acid levels, respectively. WNT10B expression was not observed in normal and benign proliferations of human breast tissue but was found to be elevated in 3 of 50 primary breast carcinomas. Southern blot analysis of the carcinoma expressing the highest level of WNT10B showed no amplification or rearrangement of the gene.
NCBI and Uniprot Product Information
NCBI Description
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It may be involved in breast cancer, and its protein signaling is likely a molecular switch that governs adipogenesis. This protein is 96% identical to the mouse Wnt10b protein at the amino acid level. This gene is clustered with another family member, WNT1, in the chromosome 12q13 region. [provided by RefSeq, Jul 2008]
Uniprot Description
WNT10B: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Defects in WNT10B are the cause of split-hand/foot malformation type 6 (SHFM6). SHFM is a limb malformation involving the central rays of the autopod and presenting with syndactyly, median clefts of the hands and feet, and aplasia and/or hypoplasia of the phalanges, metacarpals, and metatarsals. SHFM6 is a autosomal recessive disorder. Belongs to the Wnt family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 12q13
Cellular Component: extracellular space; proteinaceous extracellular matrix; extracellular region
Molecular Function: frizzled binding; receptor agonist activity
Biological Process: positive regulation of apoptosis; skeletal muscle fiber development; Wnt receptor signaling pathway through beta-catenin; negative regulation of transcription from RNA polymerase II promoter; neuron differentiation; positive regulation of cell proliferation; positive regulation of epithelial cell differentiation; chondrocyte differentiation; positive regulation of transcriptional preinitiation complex assembly; G2/M transition of mitotic cell cycle; cell cycle arrest; negative regulation of epithelial cell proliferation; smoothened signaling pathway; cell fate commitment; Wnt receptor signaling pathway; protein stabilization; sensory perception of taste; regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of bone mineralization; negative regulation of fat cell differentiation; positive regulation of osteoblast differentiation; positive regulation of transcription factor activity; regulation of skeletal muscle development; lipid metabolic process; positive regulation of anagen; myoblast cell differentiation involved in skeletal muscle regeneration
Disease: Split-hand/foot Malformation 6
Research Articles on WNT10B
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Product Notes
The Human WNT10B wnt10b (Catalog #AAA9713697) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9713697 ELISA Kit recognizes Human WNT10B. It is sometimes possible for the material contained within the vial of "Protein Wnt-10b (WNT10B), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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