Human Probable ATP-dependent RNA helicase DDX5 ELISA Kit | DDX5 elisa kit
Human Probable ATP-dependent RNA helicase DDX5 (DDX5) ELISA Kit
Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.
Inter-assay Precision (Precision between assays)
Three samples of known concentration were tested in forty separate assays to assess inter-assay precision.
CV (%) = SD/meanX100
Intra-Assay: CV
Inter-Assay: CV
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the DEAD box family of RNA helicases that are involved in a variety of cellular processes as a result of its role as an adaptor molecule, promoting interactions with a large number of other factors. This protein is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. Members of this family contain nine conserved motifs, including the conserved Asp-Glu-Ala-Asp (DEAD) motif, important to ATP binding and hydrolysis as well as RNA binding and unwinding activities. Dysregulation of this gene may play a role in cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2017]
Uniprot Description
DDX5: a putative ATP-dependent RNA helicase. A proliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor antigen. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Belongs to the DEAD box helicase family. DDX5/DDX17 subfamily. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly.
Protein type: EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 17q23.3
Cellular Component: catalytic step 2 spliceosome; cytoplasm; extracellular exosome; extracellular matrix; intracellular ribonucleoprotein complex; membrane; nucleolus; nucleoplasm; nucleus; SMAD protein complex
Molecular Function: androgen receptor binding; ATP binding; ATP-dependent RNA helicase activity; calcium-dependent protein binding; calmodulin binding; enzyme binding; mRNA 3'-UTR binding; promoter-specific chromatin binding; protein binding; R-SMAD binding; ribonucleoprotein complex binding; RNA binding; RNA helicase activity; SMAD binding
Biological Process: alternative mRNA splicing, via spliceosome; androgen receptor signaling pathway; BMP signaling pathway; cell growth; epithelial to mesenchymal transition; intracellular estrogen receptor signaling pathway; intrinsic apoptotic signaling pathway by p53 class mediator; mRNA splicing, via spliceosome; mRNA transcription; myoblast differentiation; negative regulation of transcription from RNA polymerase II promoter; nuclear-transcribed mRNA catabolic process; positive regulation of DNA damage response, signal transduction by p53 class mediator; regulation of alternative mRNA splicing, via spliceosome; regulation of osteoblast differentiation; regulation of skeletal muscle cell differentiation; regulation of transcription from RNA polymerase II promoter; regulation of viral genome replication; rhythmic process; RNA secondary structure unwinding
Research Articles on DDX5
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Product Notes
The Human DDX5 ddx5 (Catalog #AAA280878) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA280878 ELISA Kit recognizes Human DDX5. It is sometimes possible for the material contained within the vial of "Probable ATP-dependent RNA helicase DDX5, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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