4-1BB Ligand Receptor Protein Active Protein | Tnfrsf9 active protein
Recombinant Mouse 4-1BB Ligand Receptor Protein
Gene Names
Tnfrsf9; ILA; Ly63; 4-1BB; Cd137; CDw137; AA408498; AI325004; A930040I11Rik
Purity
>95% as determined by SDS-PAGE
Synonyms
4-1BB Ligand Receptor Protein; Recombinant Mouse 4-1BB Ligand Receptor Protein; Secreted CD137 antigen; Tumor necrosis factor receptor superfamily member 9; Tnfrsf9; Tnfrsf9 active protein
Host
Human Cells
Purity/Purification
>95% as determined by SDS-PAGE
Form/Format
Supplied as a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH7.4.
Sequence
Val24-Leu187
Sequence Length
211
Species
Mouse
Endotoxin
< 1.0 EU per mug as determined by the LAL method.
Fusion Tag
C-Fc
Activity
Measured by its binding ability in a functional ELISA. Immobilized mouse His-TNFSF9 at 10 mug/ml (100 mul/well) can bind mouse TNFRSF9-Fc, The EC50 of mouse TNFRSF9-Fc is 12.0-29.0 ng/ml.
Preparation and Storage
Store at < -20 degree C, stable for 6 months. Please minimize freeze-thaw cycles.
Related Product Information for Tnfrsf9 active protein
Protein Construction: Recombinant Mouse 4-1BB ligand receptor is produced by our mammalian expression system and the target gene encoding Val24-Leu187 is expressed with a Fc tag at the C-terminus.
Background: Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is a member of the tumor necrosis factor (TNF) receptor family. It can be induced by lymphocyte activation (ILA) and is expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, TNFRSF9 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. As receptor for TNFSF9/4-1BBL, it can activate T cells and the cross-linking of this protein can enhance T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice.
Background: Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is a member of the tumor necrosis factor (TNF) receptor family. It can be induced by lymphocyte activation (ILA) and is expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, TNFRSF9 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. As receptor for TNFSF9/4-1BBL, it can activate T cells and the cross-linking of this protein can enhance T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Molecular Mass: 44.7kDa
Actual Protein Molecular Mass: 60-70kDa
Actual Protein Molecular Mass: 60-70kDa
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 9 isoform 2
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 9
NCBI Official Symbol
Tnfrsf9
NCBI Official Synonym Symbols
ILA; Ly63; 4-1BB; Cd137; CDw137; AA408498; AI325004; A930040I11Rik
NCBI Protein Information
tumor necrosis factor receptor superfamily member 9
Protein Family
Research Articles on Tnfrsf9
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Product Notes
The Tnfrsf9 (Catalog #AAA2557417) is an Active Protein produced from Human Cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Val24-Leu1 87. It is sometimes possible for the material contained within the vial of "4-1BB Ligand Receptor Protein, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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