anti-Human SIRT6 Antibody | anti-SIRT6 antibody

SIRT6 Antibody

Cat. Num. AAA8526911

• Gene Names: SIRT6; SIR2L6
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Protein G-Sepharose affinity purified.
• Synonyms: SIRT6; SIRT6 Antibody; Mouse monoclonal IgG to SIRT6; anti-SIRT6 antibody

• Reactivity: Human
• Purity/Purification: Protein G-Sepharose affinity purified.
• Sequence Length: 328

• Applicable Applications for anti-SIRT6 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: ELISA: 1:5000-1:20000; WB: 1:100-1:2000
• Immunogen: Recombinant fragment of human SIRT6(C-terminus).
• Preservative: 0.02% Sodium Azide and 50% glycerol, 1% BSA, PBS, pH7.4.
• Cellular Localization: Nucleus
• Preparation and Storage: Aliquot and store at-20 degree C. Avoid repeated freeze/thaw cycles.

Testing Data

(SIRT6 antibody at 1/1000 dilution + recombinant immunogen with a DsbA tag. Predicted band size:50KDa. Observed band size:50KDa.)

Related Product Information for anti-SIRT6 antibody

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity.

NCBI and Uniprot Product Information

• NCBI GI #: 300797597
• NCBI GeneID: 51548
• NCBI Accession #: NP_001180214.1
• NCBI GenBank Nucleotide #: NM_016539.1
• UniProt Accession #: Q8N6T7; O75291; Q6IAF5; Q6PK99; Q8NCD2; Q9BSI5; Q9BWP3; Q9NRC7; Q9UQD1; B2RCD0
• Molecular Weight: 36,065 Da
• NCBI Official Full Name: NAD-dependent protein deacetylase sirtuin-6 isoform 2
• NCBI Official Synonym Full Names: sirtuin 6
• NCBI Official Symbol: SIRT6
• NCBI Official Synonym Symbols: SIR2L6
• NCBI Protein Information: NAD-dependent protein deacetylase sirtuin-6
• UniProt Protein Name: NAD-dependent protein deacetylase sirtuin-6
• Protein Family: NAD-dependent protein deacetylase
• UniProt Gene Name: SIRT6
• UniProt Synonym Gene Names: SIR2L6

NCBI Description

This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

Uniprot Description

NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD+ in the absence of acetylated substrate.