Human huntingtin interacting protein 1 ELISA Kit | HIP1 elisa kit

Human huntingtin interacting protein 1, HIP1 ELISA Kit

Cat. Num. AAA9310606

• Gene Names: HIP1; HIP-I; ILWEQ
• Reactivity: Human
• Synonyms: huntingtin interacting protein 1; Human huntingtin interacting protein 1; HIP1 ELISA Kit; Human huntingtin interacting protein 1 (HIP1) ELISA Kit; ILWEQ; MGC126506; ; HIP1 elisa kit

• Reactivity: Human

• Samples: Duck Body Fluids And Tissue Homogenates
• Assay Type: Quantitative Sandwich
• Detection Range: 3.12pg/ml-100pg/ml
• Sensitivity: 1.0pg/ml.
• Intra-assay Precision: Intra-assay CV (%) is less than 15%
• Inter-assay Precision: Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100]. All CV% should be compared by concentration, not compared by OD values.
• Preparation and Storage: Store all reagents at 2-8 degree C

Related Product Information for HIP1 elisa kit

Background/Introduction: This Quantitative Sandwich ELISA kit is for lab reagent/research use only! This kit is intended to be used for determine the level of HIF2A (hereafter termed "analyte") in undiluted original Duck body fluids and tissue homogenates. This kit is NOT suitable for assaying non-biological sources of substances.

NCBI and Uniprot Product Information

• NCBI GI #: 342307096
• NCBI GeneID: 3092
• NCBI Accession #: NP_001230127.1
• NCBI GenBank Nucleotide #: NM_001243198.2
• UniProt Accession #: O00291; O00328; Q2TB58; Q8TDL4; B4E3I7; E7ES17
• Molecular Weight: 116,221 Da
• NCBI Official Full Name: huntingtin-interacting protein 1 isoform 2
• NCBI Official Synonym Full Names: huntingtin interacting protein 1
• NCBI Official Symbol: HIP1
• NCBI Official Synonym Symbols: HIP-I; ILWEQ
• NCBI Protein Information: huntingtin-interacting protein 1; huntingtin-interacting protein I
• UniProt Protein Name: Huntingtin-interacting protein 1
• Protein Family: Histidine permease
• UniProt Gene Name: HIP1
• UniProt Synonym Gene Names: HIP-1; HIP-I
• UniProt Entry Name: HIP1_HUMAN

NCBI Description

The product of this gene is a membrane-associated protein that functions in clathrin-mediated endocytosis and protein trafficking within the cell. The encoded protein binds to the huntingtin protein in the brain; this interaction is lost in Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Uniprot Description

HIP1: Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors. A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;7)(q33;q11.2) with PDGFRB. The chimeric HIP1-PDGFRB transcript results from an in-frame fusion of the two genes. The reciprocal PDGFRB-HIP1 transcript is not expressed. Belongs to the SLA2 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Cytoskeletal

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: Golgi apparatus; cytoskeleton; clathrin-coated vesicle; membrane; intracellular membrane-bound organelle; cytoplasm; clathrin coated vesicle membrane; nucleus

Molecular Function: protein binding, bridging; clathrin binding; protein binding; structural constituent of cytoskeleton; actin binding; phosphoinositide binding

Biological Process: regulation of apoptosis; caspase activation; clathrin cage assembly; regulation of transcription, DNA-dependent; transcription, DNA-dependent; apoptosis; endocytosis; actin cytoskeleton organization and biogenesis; cell differentiation; positive regulation of receptor-mediated endocytosis

Disease: Prostate Cancer