Rabbit anti-Human HIP1 Polyclonal Antibody | anti-HIP1 antibody

HIP1 Polyclonal Antibody

Cat. Num. AAA9416270

• Gene Names: HIP1; SHON; HIP-I; ILWEQ; SHONbeta; SHONgamma
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry
• Purity: Antigen Affinity Purified
• Synonyms: HIP1; Polyclonal Antibody; HIP1 Polyclonal Antibody; HIP-1; Huntingtin-interacting protein I; HIP-I; anti-HIP1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous level of total HIP1 polyclonal antibody.
• Purity/Purification: Antigen Affinity Purified
• Form/Format: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 986

• Applicable Applications for anti-HIP1 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Western Blot: 1:500 - 1:1000; Immunohistochemistry: 1:20 - 1:200
• Immunogen: Recombinant Human Huntingtin-interacting protein 1 protein(410-690aa)
• Immunogen Type: Protein
• Preparation and Storage: Store at -20 degree C

Western Blot (WB)

(All lanes: HIP1 antibody at 4ug/ml+A549 whole cell lysate)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded human colorectal carcinoma using at dilution of 1:100.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded human placenta using at dilution of 1:100.)

Related Product Information for anti-HIP1 antibody

Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway.Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors.

Product Categories/Family for anti-HIP1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 342307096
• NCBI GeneID: 3092
• NCBI Accession #: NP_001230127.1
• NCBI GenBank Nucleotide #: NM_001243198.2
• UniProt Accession #: O00291; O00328; Q2TB58; Q8TDL4; B4E3I7; E7ES17; V5LU97
• Molecular Weight: 113,076 Da
• NCBI Official Full Name: huntingtin-interacting protein 1 isoform 2
• NCBI Official Synonym Full Names: huntingtin interacting protein 1
• NCBI Official Symbol: HIP1
• NCBI Official Synonym Symbols: SHON; HIP-I; ILWEQ; SHONbeta; SHONgamma
• NCBI Protein Information: huntingtin-interacting protein 1
• UniProt Protein Name: Huntingtin-interacting protein 1
• Protein Family: Histidine permease
• UniProt Gene Name: HIP1
• UniProt Synonym Gene Names: HIP-1; HIP-I
• UniProt Entry Name: HIP1_HUMAN

Uniprot Description

HIP1: Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors. A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;7)(q33;q11.2) with PDGFRB. The chimeric HIP1-PDGFRB transcript results from an in-frame fusion of the two genes. The reciprocal PDGFRB-HIP1 transcript is not expressed. Belongs to the SLA2 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Cytoskeletal

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: AP-2 adaptor complex; clathrin-coated vesicle; cytoplasm; cytoskeleton; Golgi apparatus; intracellular membrane-bound organelle; membrane; nucleus

Molecular Function: actin filament binding; clathrin binding; clathrin light chain binding; epidermal growth factor receptor binding; glutamate receptor binding; phosphatidylinositol 3-phosphate binding; phosphatidylinositol-3,4-bisphosphate binding; phosphatidylinositol-4,5-bisphosphate binding; phosphoinositide binding; protein binding; protein heterodimerization activity; protein homodimerization activity; structural constituent of cytoskeleton

Biological Process: apoptosis; caspase activation; clathrin cage assembly; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of protein kinase B signaling cascade; positive regulation of receptor-mediated endocytosis; protein stabilization; regulation of apoptosis

Disease: Prostate Cancer