Typical Testing Data/Standard Curve (for reference only)
Mouse Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 ELISA Kit | Hcn4 elisa kit
Mouse Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
Uniprot Description
HCN4: Hyperpolarization-activated ion channel with very slow activation and inactivation exhibiting weak selectivity for potassium over sodium ions. May contribute to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP. May mediate responses to sour stimuli. Defects in HCN4 are a cause of sick sinus syndrome type 2 (SSS2); also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. The term 'sick sinus syndrome' encompasses a variety of conditions caused by sinus node dysfunction. The most common clinical manifestations are syncope, presyncope, dizziness, and fatigue. Electrocardiogram typically shows sinus bradycardia, sinus arrest, and/or sinoatrial block. Episodes of atrial tachycardias coexisting with sinus bradycardia ('tachycardia-bradycardia syndrome') are also common in this disorder. SSS occurs most often in the elderly associated with underlying heart disease or previous cardiac surgery, but can also occur in the fetus, infant, or child without heart disease or other contributing factors, in which case it is considered to be a congenital disorder. Defects in HCN4 are the cause of Brugada syndrome type 8 (BRGDA8). A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset. Belongs to the potassium channel HCN family.
Protein type: Membrane protein, multi-pass; Channel, cation; Membrane protein, integral
Cellular Component: basolateral plasma membrane; cell soma; integral to membrane; intrinsic to plasma membrane; membrane; neuron projection; perinuclear region of cytoplasm; plasma membrane; terminal button
Molecular Function: cAMP binding; identical protein binding; intracellular cAMP activated cation channel activity; ion channel activity; nucleotide binding; potassium channel activity; protein binding; sodium channel activity; voltage-gated ion channel activity; voltage-gated potassium channel activity; voltage-gated sodium channel activity
Biological Process: cation transport; in utero embryonic development; ion transport; potassium ion transport; regulation of heart contraction; regulation of heart rate; regulation of membrane potential; sodium ion transport; transmembrane transport; transport
Research Articles on Hcn4
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Product Notes
The Mouse Hcn4 hcn4 (Catalog #AAA288155) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA288155 ELISA Kit recognizes Mouse Hcn4. It is sometimes possible for the material contained within the vial of "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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