Typical Testing Data/Standard Curve (for reference only)
Human Potassium, Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2 (HCN2) ELISA Kit | HCN2 elisa kit
Human Potassium, Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2 (HCN2) ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
Principle of the Assay: This kit is an Enzyme-Linked Immunosorbent Assay (ELISA). The plate has been pre-coated with human KCNQ1 antibody. KCNQ1 present in the sample is added and binds to antibodies coated on the wells. And then biotinylated human KCNQ1 Antibody is added and binds to KCNQ1 in the sample. Then Streptavidin-HRP is added and binds to the Biotinylated KCNQ1 antibody. After incubation unbound Streptavidin-HRP is washed away during a washing step. Substrate solution is then added and color develops in proportion to the amount of human KCNQ1. The reaction is terminated by addition of acidic stop solution and absorbance is measured at 450 nm.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a hyperpolarization-activated cation channel involved in the generation of native pacemaker activity in the heart and in the brain. The encoded protein is activated by cAMP and can produce a fast, large current. Defects in this gene were noted as a possible cause of some forms of epilepsy. [provided by RefSeq, Jan 2017]
Uniprot Description
HCN2: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages. Belongs to the potassium channel HCN family.
Protein type: Membrane protein, multi-pass; Channel, cation; Membrane protein, integral
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: voltage-gated potassium channel complex; integral to plasma membrane; plasma membrane
Molecular Function: identical protein binding; voltage-gated potassium channel activity; intracellular cAMP activated cation channel activity; voltage-gated sodium channel activity; cAMP binding
Biological Process: synaptic transmission; regulation of membrane potential; cell-cell signaling
Research Articles on HCN2
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Product Notes
The Human HCN2 hcn2 (Catalog #AAA1603225) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA1603225 ELISA Kit recognizes Human HCN2. It is sometimes possible for the material contained within the vial of "Potassium, Sodium Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2 (HCN2), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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