Ectodysplasin A2 Recombinant Protein | Eda2r recombinant protein

Recombinant Mouse Ectodysplasin A2 Receptor Protein

Cat. Num. AAA2556779

• Gene Names: Eda2r; Xedar; TNFRSF27; 9430060M22Rik
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: Ectodysplasin A2; Recombinant Mouse Ectodysplasin A2 Receptor Protein; Ectodysplasin A2 receptor; EDA-A2 receptor; EDA-A2R; Tumor Necrosis Factor Receptor Superfamily Member XEDAR; Tumor Necrosis Factor Receptor Superfamily Member 27; X-linked ectodysplasin-A2 receptor; EDAA2R; TNFRSF27; XEDAR; EDAR2; Eda2r recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of PBS, pH 7.4.
• Sequence Length: 297

• Species: Mouse
• Endotoxin: <1.0 EU per mug as determined by LAL test.
• Fragment: Met1-Thr138
• Fusion Tag: C-6His
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days.; Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

SDS-Page

Related Product Information for Eda2r recombinant protein

Protein Construction: Recombinant Mouse Ectodysplasin A2 Receptor is produced by our Mammalian expression system and the target gene encoding Met1-Thr138 is expressed with a 6His tag at the C-terminus.

Background: Tumor necrosis factor receptor superfamily member 27, also known as XEDAR and EDA2R, is a type III transmembrane protein of the TNFR superfamily. EDA2R consists of extracellular domain (ECD) with 3 cysteine-rich repeats and a single transmembrane domain but lacks an N-terminal signal peptide. EDA2R is widely expressed, notably in embryonic basal epidermal cells and maturing hair follicles. Even though it does not contain a cytoplasmic death domain, EDA2R can associate with Fas and induce EDA-A2 dependent apoptosis. Its transcription is directly induced by p53, and it mediated cell death is p53 dependent. it is down-regulated in breast, colon, and lung cancers, particularly in cases with p53 mutations. It also plays a role in EDA-A2 induced skeletal muscle degeneration and osteoblast differentiation. Mutations in the EDA gene are associated with the X-linked form of Hypohidrotic Ectodermal Dysplasia (HED), a disease typically characterized by abnormal hair, teeth and sweat glands.

NCBI and Uniprot Product Information

• NCBI GI #: 238637340
• NCBI GeneID: 245527
• NCBI Accession #: NP_001154904.1
• NCBI GenBank Nucleotide #: NM_001161432.1
• UniProt Accession #: Q8BX35; Q8BM50
• Molecular Weight: Molecular Mass: 16.4kDa; Actual Protein Molecular Mass: 26kDa
• NCBI Official Full Name: tumor necrosis factor receptor superfamily member 27
• NCBI Official Synonym Full Names: ectodysplasin A2 receptor
• NCBI Official Symbol: Eda2r
• NCBI Official Synonym Symbols: Xedar; TNFRSF27; 9430060M22Rik
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 27
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 27
• Protein Family: Tumor necrosis factor receptor superfamily
• UniProt Gene Name: Eda2r
• UniProt Synonym Gene Names: Tnfrsf27; Xedar; EDA-A2 receptor

Uniprot Description

Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6 ().