EDA2R recombinant protein

EDA2R, 1-138aa, Human, hIgG-His-tag, Baculovirus

Cat. Num. AAA206537

• Gene Names: EDA2R; XEDAR; EDAA2R; EDA-A2R; TNFRSF27
• Applications: SDS-Page
• Purity: > 90% by SDS-PAGE
• Synonyms: EDA2R; 1-138aa; Human; hIgG-His-tag; Baculovirus; Tumor necrosis factor receptor superfamily member 27 isoform 2; EDA-A2R; EDAA2R; TNFRSF27; XEDAR; EDA2R recombinant protein

• Host: Baculovirus
• Purity/Purification: > 90% by SDS-PAGE
• Form/Format: Liquid. In phosphate buffered saline (pH 7.4) containing 20% glycerol, 1mM DTT.
• Concentration: 0.5 mg/ml (determined by Absorbance at 280nm) (varies by lot)
• Sequence: ADPMDCQENE YWDQWGRCVT CQRCGPGQEL SKDCGYGEGG DAYCTACPPR RYKSSWGHHR CQSCITCAVI NRVQKVNCTA TSNAVCGDCL PRFYRKTRIG GLQDQECIPC TKQTPTSEVQ CAFQLSLVEA DAPTVPPQEA TLEPKSCDKT HTCPPCPAPE LLGGPSVFLF PPKPKDTLMI SRTPEVTCVV VDVSHEDPEV KFNWYVDGVE VHNAKTKPRE EQYNSTYRVV SVLTVLHQDW LNGKEYKCKV SNKALPAPIE KTISKAKGQP REPQVYTLPP SRDELTKNQV SLTCLVKGFY PSDIAVEWES NGQPENNYKT TPPVLDSDGS FFLYSKLTVD KSRWQQGNVF SCSVMHEALH NHYTQKSLSL SPGKHHHHHH
• Sequence Length: 318

• Applicable Applications for EDA2R recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: hIgG-His-tag
• Endotoxin Level: < 1.0 EU per 1 microgram of protein (determined by LAL method)
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for EDA2R recombinant protein

EDA2R also known as Tumor necrosis factor receptor superfamily member 27 isoform 2, is a transmembrane protein in the TNF receptor superfamily. This protein itself is strongly associated with androgenetic alopecia (male hair loss). It is widely expressed, notably in embryonic basal epidermal cells and maturing hair follicles. Even though it does not contain a cytoplasmic death domain, it can associate with Fas and induce EDA-A2 dependent apoptosis. Recombinant human EDA2R protein, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Categories/Family for EDA2R recombinant protein

Apoptosis

References

Brosh R., et al. (2010) FEBS Lett. 584:2473-2477; Redler S., et al. (2012) Br J Dermatol. 166:1314-1318

NCBI and Uniprot Product Information

• NCBI GI #: 334085255
• NCBI GeneID: 60401
• NCBI Accession #: NP_001229239
• NCBI GenBank Nucleotide #: NM_001242310.1
• UniProt Accession #: Q9HAV5; Q5VYX9; Q5VYY0; Q6UWM2; Q8IZA6
• Molecular Weight: 42.5kDa (380aa) 40-57KDa (SDS-PAGE under reducing conditions.)
• NCBI Official Full Name: tumor necrosis factor receptor superfamily member 27 isoform 2
• NCBI Official Synonym Full Names: ectodysplasin A2 receptor
• NCBI Official Symbol: EDA2R
• NCBI Official Synonym Symbols: XEDAR; EDAA2R; EDA-A2R; TNFRSF27
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 27
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 27
• Protein Family: Tumor necrosis factor receptor superfamily
• UniProt Gene Name: EDA2R
• UniProt Synonym Gene Names: TNFRSF27; XEDAR; EDA-A2 receptor

NCBI Description

The protein encoded by this gene is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains cysteine-rich repeats and a single transmembrane domain. This protein binds to the EDA-A2 isoform of ectodysplasin, which plays an important role in maintenance of hair and teeth. Alternatively spliced transcript variants encodes distinct protein isoforms. [provided by RefSeq, Apr 2016]

Uniprot Description

Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6.