XEDAR / EDA2R recombinant protein

Recombinant Mouse XEDAR / EDA2R Protein (Fc tag)

Cat. Num. AAA2546996

• Gene Names: Eda2r; Xedar; TNFRSF27; 9430060M22Rik
• Purity: > 95 % as determined by SDS-PAGE
• Synonyms: XEDAR / EDA2R; Recombinant Mouse XEDAR / EDA2R Protein (Fc tag); EDA2R; Tnfrsf27; Xedar; XEDAR / EDA2R recombinant protein

• Host: Human Cells
• Purity/Purification: > 95 % as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH 7.4
• Sequence Length: 297

• Application Notes: The recombinant mouse EDA2R /Fc is a disulfide-linked homodimer. The reduced monomer comprises 379 amino acids and has a predicted molecular mass of 42.4 kDa. The apparent molecular mass of the protein is approximately 49 kDa in SDS-PAGE under reducing conditions due to glycosylation.
• Predicted N Terminal: Met
• Endotoxin: < 1.0 EU per mug of the protein as determined by the LAL method
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -70 degree C

SDS-PAGE

Related Product Information for XEDAR / EDA2R recombinant protein

Background: Tumor necrosis factor receptor superfamily member 27, also known as X-linked ectodysplasin-A2 receptor, EDA-A2 receptor, EDA2R, XEDAR and TNFRSF27, is a single-pass type I II membrane protein. TNFRSF27 / EDA2R contains three TNFR-Cys repeats. It is a new member of the tumor necrosis factor receptor family that has been shown to be highly expressed in ectodermal derivatives during embryonic development and binds to ectodysplasin-A2 (EDA-A2). TNFRSF27 / EDA2R is a receptor for EDA isoform A2, but not for EDA isoform A1. TNFRSF27 / EDA2R mediates the activation of the NF-kappa-B and JNK pathways. The activation seems to be mediated by binding to TRAF3 and TRAF6. Ectodysplasin, a member of the tumor necrosis factor family, is encoded by the anhidrotic ectodermal dysplasia EDA gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that differ only by an insertion of two amino acids. This insertion functions to determine receptor binding specificity, such that EDA-A1 binds only the receptor EDAR, whereas EDA-A2 binds only the related, but distinct, X-linked ectodysplasin-A2 receptor (XEDAR).

Description: A DNA sequence encoding the mouse EDA2R (Q8BX35) (Met1-Thr138) was expressed, fused with the Fc region of human IgG1 at the C-terminus.

NCBI and Uniprot Product Information

• NCBI GI #: 238637340
• NCBI GeneID: 245527
• NCBI Accession #: NP_001154904.1
• NCBI GenBank Nucleotide #: NM_001161432.1
• UniProt Accession #: Q8BX35; Q8BM50
• Molecular Weight: 33,066 Da
• NCBI Official Full Name: tumor necrosis factor receptor superfamily member 27
• NCBI Official Synonym Full Names: ectodysplasin A2 receptor
• NCBI Official Symbol: Eda2r
• NCBI Official Synonym Symbols: Xedar; TNFRSF27; 9430060M22Rik
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 27
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 27
• UniProt Gene Name: Eda2r
• UniProt Synonym Gene Names: Tnfrsf27; Xedar; EDA-A2 receptor

Uniprot Description

EDA2R: Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: X|X C3

Cellular Component: intracellular; plasma membrane

Molecular Function: receptor activity

Biological Process: activation of NF-kappaB transcription factor; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JNK cascade; programmed cell death; tissue development