XEDAR / EDA2R recombinant protein
Recombinant Mouse XEDAR / EDA2R Protein (Fc tag)
Gene Names
Eda2r; Xedar; TNFRSF27; 9430060M22Rik
Purity
> 95 % as determined by SDS-PAGE
Synonyms
XEDAR / EDA2R; Recombinant Mouse XEDAR / EDA2R Protein (Fc tag); EDA2R; Tnfrsf27; Xedar; XEDAR / EDA2R recombinant protein
Host
Human Cells
Purity/Purification
> 95 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH 7.4
Sequence Length
297
Application Notes
The recombinant mouse EDA2R /Fc is a disulfide-linked homodimer. The reduced monomer comprises 379 amino acids and has a predicted molecular mass of 42.4 kDa. The apparent molecular mass of the protein is approximately 49 kDa in SDS-PAGE under reducing conditions due to glycosylation.
Predicted N Terminal
Met
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
SDS-PAGE
Related Product Information for XEDAR / EDA2R recombinant protein
Background: Tumor necrosis factor receptor superfamily member 27, also known as X-linked ectodysplasin-A2 receptor, EDA-A2 receptor, EDA2R, XEDAR and TNFRSF27, is a single-pass type I II membrane protein. TNFRSF27 / EDA2R contains three TNFR-Cys repeats. It is a new member of the tumor necrosis factor receptor family that has been shown to be highly expressed in ectodermal derivatives during embryonic development and binds to ectodysplasin-A2 (EDA-A2). TNFRSF27 / EDA2R is a receptor for EDA isoform A2, but not for EDA isoform A1. TNFRSF27 / EDA2R mediates the activation of the NF-kappa-B and JNK pathways. The activation seems to be mediated by binding to TRAF3 and TRAF6. Ectodysplasin, a member of the tumor necrosis factor family, is encoded by the anhidrotic ectodermal dysplasia EDA gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that differ only by an insertion of two amino acids. This insertion functions to determine receptor binding specificity, such that EDA-A1 binds only the receptor EDAR, whereas EDA-A2 binds only the related, but distinct, X-linked ectodysplasin-A2 receptor (XEDAR).
Description: A DNA sequence encoding the mouse EDA2R (Q8BX35) (Met1-Thr138) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
Description: A DNA sequence encoding the mouse EDA2R (Q8BX35) (Met1-Thr138) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
33,066 Da
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 27
NCBI Official Synonym Full Names
ectodysplasin A2 receptor
NCBI Official Symbol
Eda2r
NCBI Official Synonym Symbols
Xedar; TNFRSF27; 9430060M22Rik
NCBI Protein Information
tumor necrosis factor receptor superfamily member 27
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 27
UniProt Gene Name
Eda2r
UniProt Synonym Gene Names
Tnfrsf27; Xedar; EDA-A2 receptor
Uniprot Description
EDA2R: Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: X|X C3
Cellular Component: intracellular; plasma membrane
Molecular Function: receptor activity
Biological Process: activation of NF-kappaB transcription factor; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of JNK cascade; programmed cell death; tissue development
