LIGHT active protein
Mouse LIGHT
Gene Names
Tnfsf14; LTg; HVEML; LIGHT; Ly113; HVEM-L
Reactivity
Mouse
Purity
> 98% by SDS-PAGE and HPLC analysis
Synonyms
LIGHT; Mouse LIGHT; Recombinant Murine LIGHT; LIGHT active protein
Host
E Coli
Reactivity
Mouse
Purity/Purification
> 98% by SDS-PAGE and HPLC analysis
Form/Format
Lyophilized
Sequence
MRLHQRLGDI VAHLPDGGKG SWEKLIQDQR SHQANPAAHL TGANAS LIGI GGPLLWETRL GLAFLRGLTY HDGALVTMEP GYYYVYSKVQ L SGVGCPQGL ANGLPITHGL YKRTSRYPKE LELLVSRRSP CGRANSS RVW WDSSFLGGVV HLEAGEEVVV RVPGNRLVRP RDGTRSYFGA FM V
Sequence Length
239
Endotoxin Level
< 0.1 ng per ug of LIGHT
Biological Activity
Testing in progress.
Related Product Information for LIGHT active protein
LIGHT belongs to the TNF family of ligands, and can signal through the herpes virus entry mediator type A receptor (HVEM, TNFRSF14), LTbetaR, or bind to a decoy receptor, DcR3. It is expressed in splenocytes, activated PBL, CD+8 tumor infiltrating lymphocytes, granulocytes, and monocytes. LIGHT has the ability to active NFkB, to co-stimulate the activation of lymphocytes and to induce apoptosis in certain human tumor cells. Recombinant murine LIGHT is a 20.1 kDa protein containing 183 amino acid residues.
Product Categories/Family for LIGHT active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
20.1 kDa
NCBI Official Full Name
tumor necrosis factor ligand superfamily member 14
NCBI Official Synonym Full Names
tumor necrosis factor (ligand) superfamily, member 14
NCBI Official Symbol
Tnfsf14
NCBI Official Synonym Symbols
LTg; HVEML; LIGHT; Ly113; HVEM-L
NCBI Protein Information
tumor necrosis factor ligand superfamily member 14
UniProt Protein Name
Tumor necrosis factor ligand superfamily member 14
Protein Family
UniProt Gene Name
Tnfsf14
UniProt Synonym Gene Names
Light
UniProt Entry Name
TNF14_MOUSE
Uniprot Description
Function: Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB and stimulates the proliferation of T-cells.
Subunit structure: Homotrimer
By similarity.
Subcellular location: Cell membrane; Single-pass type II membrane protein
By similarity. Tumor necrosis factor ligand superfamily member 14, soluble form: Secreted
By similarity.
Post-translational modification: The soluble form derives from the membrane form by proteolytic processing.
Sequence similarities: Belongs to the tumor necrosis factor family.
Research Articles on LIGHT
Similar Products
Product Notes
The LIGHT tnfsf14 (Catalog #AAA691997) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Mouse LIGHT reacts with Mouse and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: MRLHQRLGDI VAHLPDGGKG SWEKLIQDQR SHQANPAAHL TGANAS LIGI GGPLLWETRL GLAFLRGLTY HDGALVTMEP GYYYVYSKVQ L SGVGCPQGL ANGLPITHGL YKRTSRYPKE LELLVSRRSP CGRANSS RVW WDSSFLGGVV HLEAGEEVVV RVPGNRLVRP RDGTRSYFGA FM V. It is sometimes possible for the material contained within the vial of "LIGHT, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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