Rabbit anti-Mouse TNFSF14 Polyclonal Antibody | anti-TNFSF14 antibody

TNFSF14 polyclonal antibody

Cat. Num. AAA3013778

• Gene Names: Tnfsf14; LTg; HVEML; LIGHT; Ly113; HVEM-L
• Reactivity: Mouse
• Applications: Western Blot
• Purity: affinity purified by Protein A
• Synonyms: TNFSF14; Polyclonal Antibody; TNFSF14 polyclonal antibody; CD 258; CD258; CD258 antigen; Delta transmembrane LIGHT; Herpes virus entry mediator ligand; Herpesvirus entry mediator A; Herpesvirus entry mediator ligand; herpesvirus entry mediator-ligand; HVEM L; HVEM-L; HVEML; Ligand for herpesvirus entry mediator; LIGHT; LTg; soluble form; TNF14; TNF14_HUMAN; TNFSF 14; TNFSF14 protein; TR 2; TR2; Tumor necrosis factor (ligand) superfamily; member 14; Tumor necrosis factor ligand superfamily member 14; Tumor necrosis factor ligand superfamily; Tumor necrosis factor receptor like 2; tumor necrosis factor receptor-like 2; Tumor necrosis factor superfamily member 14; Tumor necrosis factor superfamily member LIGHT; anti-TNFSF14 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Specificity: TNFSF14 polyclonal Antibody detects endogenous levels of TNFSF14 protein.
• Purity/Purification: affinity purified by Protein A
• Form/Format: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

• Applicable Applications for anti-TNFSF14 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-2000
• Immunogen: KLH conjugated synthetic peptide derived from mouse TNFSF14:59-130/239
• Preparation and Storage: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Testing Data

(Anti-TNFSF14 at 1/1000 dilution)

Testing Data

(Anti- TNFSF14 at 1/1000 dilution)

Related Product Information for anti-TNFSF14 antibody

LIGHT protein is a type II transmembrane protein and a tumor necrosis factor (TNF) ligand superfamily member (TNFSF14). LIGHT is expressed on activated T cells and immature dendritic cells and its receptors have been identified as lymphotoxin-Beta receptor (LTBetaR) and the herpesvirus entry mediator (HVEM), both of which lack the cytoplasmic sequence termed as "death domain." LIGHT is first identified as HVEM ligand (HVEM-L) and a deterrent to herpesvirus infection according to its ability to compete with HSV glycoprotein D for HVEM binding. As a T cell-derived costimulatory ligand, TNFSF14 plays a crucial role in T cell activation and proliferation by LIGHT-LTBetaR interaction, and it is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells. Additionally, recent studies also establish a direct role for LIGHT in NK activation/expansion via LIGHT-HVEM interaction, and thus breaking T-cell tolerance at the tumor site. Accordingly, LIGHT is suggested to be involved in CTL-mediated tumor rejection, allograft rejection and graft versus host disease. Although known as lymphotoxin-Gamma, LIGHT plays a minimal role in lymphoid tissue development in contrast with LT-Alpha and Beta. This protein was also demonstrated to inhibit TNF-Alpha-mediated but not Fas- or TRAIL-mediated apoptosis of human primary hepatocytes.

NCBI and Uniprot Product Information

• NCBI GI #: 9507195
• NCBI GeneID: 50930
• NCBI Accession #: NP_062291.1
• NCBI GenBank Nucleotide #: NM_019418.3
• UniProt Accession #: Q9QYH9; Q059Y9
• Molecular Weight: 26,338 Da
• NCBI Official Full Name: tumor necrosis factor ligand superfamily member 14
• NCBI Official Synonym Full Names: tumor necrosis factor (ligand) superfamily, member 14
• NCBI Official Symbol: Tnfsf14
• NCBI Official Synonym Symbols: LTg; HVEML; LIGHT; Ly113; HVEM-L
• NCBI Protein Information: tumor necrosis factor ligand superfamily member 14
• UniProt Protein Name: Tumor necrosis factor ligand superfamily member 14
• Protein Family: Tumor necrosis factor ligand superfamily
• UniProt Gene Name: Tnfsf14
• UniProt Synonym Gene Names: Light
• UniProt Entry Name: TNF14_MOUSE

Uniprot Description

TNFSF14: Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Inhibitor; Membrane protein, integral

Cellular Component: extracellular space; membrane; integral to membrane; extracellular region; plasma membrane

Molecular Function: caspase inhibitor activity; cytokine activity; tumor necrosis factor receptor binding; receptor binding

Biological Process: release of cytoplasmic sequestered NF-kappaB; T cell costimulation; immune response; negative regulation of caspase activity; positive regulation of myoblast differentiation