Flt-3 Ligand active protein
Mouse Flt-3 Ligand
Gene Names
Flt3l; Ly72L; Flt3lg
Reactivity
Mouse
Purity
> 98% by SDS-PAGE and HPLC
Synonyms
Flt-3 Ligand; Mouse Flt-3 Ligand; Recombinant Murine flt3-Ligand; Flt-3 Ligand active protein
Host
E Coli
Reactivity
Mouse
Purity/Purification
> 98% by SDS-PAGE and HPLC
Form/Format
Lyophilized
Sequence
MTPDCYFSHS PISSNFKVKF RELTDHLLKD YPVTVAVNLQ DEKHCK ALWS LFLAQRWIEQ LKTVAGSKMQ TLLEDVNTEI HFVTSCTFQP L PECLRFVQT NISHLLKDTC TQLLALKPCI GKACQNFSRC LEVQCQP DSS TLLPPRSPIA LEATELPEPR PRQ
Sequence Length
232
Endotoxin Level
< 0.1 ng per ug of flt3-Ligand
Biological Activity
Determined by the dose-dependent stimulation of the proliferation of human AML5 cells. The expected ED50 for this effect is 5.0 - 8.0 ng/ml.
Related Product Information for Flt-3 Ligand active protein
Flt3 Ligand, also known as FL, is an alpha-helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages. Mature mouse Flt3 Ligand consists of a 161 amino acid (aa) extracellular domain (ECD) with a cytokinelike domain and a juxtamembrane tether region, a 21 aa transmembrane segment, and a 22 aa cytoplasmic tail. Within the ECD, mouse Flt3 Ligand shares 71% and 81% aa sequence identity with human and rat Flt3 Ligand, respectively. Mouse and human Flt3 Ligand show cross-species activity. Flt3 Ligand is expressed as a non-covalently-linked dimer by T cells and bone marrow and thymic fibroblasts. Each 36 kDa chain carries approximately 12 kDa of N- and O-linked carbohydrates. Alternate splicing and proteolytic cleavage of the transmembrane form can generate a soluble 30 kDa fragment that includes the cytokine domain. Alternate splicing of mouse Flt3 Ligand also generates a membrane-associated isoform with a 57 aa substitution following the cytokine domain. Both transmembrane and soluble Flt3 Ligand signal through the tyrosine kinase receptor Flt3/ Flk2.
Product Categories/Family for Flt-3 Ligand active protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
18.6 kDa
NCBI Official Full Name
fms-related tyrosine kinase 3 ligand
NCBI Official Synonym Full Names
FMS-like tyrosine kinase 3 ligand
NCBI Official Symbol
Flt3l
NCBI Official Synonym Symbols
Ly72L; Flt3lg
NCBI Protein Information
fms-related tyrosine kinase 3 ligand; flt3 ligand
UniProt Protein Name
Fms-related tyrosine kinase 3 ligand
UniProt Gene Name
Flt3lg
UniProt Synonym Gene Names
Flt3l; Flt3 ligand; Flt3L
UniProt Entry Name
FLT3L_MOUSE
Uniprot Description
Function: Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.
Subunit structure: Homodimer (soluble isoform)
By similarity.
Subcellular location: Cell membrane; Single-pass type I membrane protein. Isoform 3: Secreted. Note: Biologically active.Isoform 4: Secreted. Note: Inactive.
Research Articles on Flt-3 Ligand
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Product Notes
The Flt-3 Ligand flt3lg (Catalog #AAA691629) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Mouse Flt-3 Ligand reacts with Mouse and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: MTPDCYFSHS PISSNFKVKF RELTDHLLKD YPVTVAVNLQ DEKHCK ALWS LFLAQRWIEQ LKTVAGSKMQ TLLEDVNTEI HFVTSCTFQP L PECLRFVQT NISHLLKDTC TQLLALKPCI GKACQNFSRC LEVQCQP DSS TLLPPRSPIA LEATELPEPR PRQ. It is sometimes possible for the material contained within the vial of "Flt-3 Ligand, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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