Testing Data
flt-3-Ligand Active Protein | Flt3-L active protein
flt-3-Ligand, murine recombinant
Gene Names
Flt3l; Ly72L; Flt3lg
Applications
SDS-Page
Purity
>=98%
Synonyms
flt-3-Ligand; murine recombinant; Fms-related tyrosine kinase 3 ligand; Short name=Flt3 ligand; Short name=Flt3L; SL cytokine; Flt3-L active protein
Host
E Coli
Purity/Purification
>=98%
Form/Format
Sterile filtered and lyophilized with no additives.
Appearance: Lyophilized protein
Appearance: Lyophilized protein
Sequence Length
232
Applicable Applications for Flt3-L active protein
SDS-PAGE; HPLC
Solubility/Reconstitution Instructions
Reconstitute in H?O to a concentration of 0.1 - 1.0 mg/ml. The solution can then be diluted into other aqueous buffers and stored at 4 degree C for 1 week or -20 degree C for future use.
Endotoxin Level
<0.1 ng/mug
Biological Activity
Determined by the dose dependent proliferation of mouse AML5 cells
Results
5-8 ng/ml
Handling
Centrifuge the vial prior to opening.
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Shelf Life: 12 months
Testing Data
Testing Data
Related Product Information for Flt3-L active protein
Background: Flt3-Ligand belongs to a small group of growth factors that regulate proliferation of early hematopoietic cells. Multiple isoforms of Flt3-Ligand have been identified. The predominant form is the transmembrane which is biologically active on the cell surface. The proteolytically cleaved transmembrane isoform generates a soluble form, which is also biologically active. Flt3-Ligand binds to cells expressing the tyrosine kinase receptor Flt3. Flt3-Ligand alone cannot stimulate proliferation, but synergizes well with other CSFs and interleukins to induce growth and differentiation. Recombinant murine flt3-Ligand is a 16.4 kDa protein containing 144 amino acid residues.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
16.4 kDa
NCBI Official Full Name
fms-related tyrosine kinase 3 ligand
NCBI Official Synonym Full Names
FMS-like tyrosine kinase 3 ligand
NCBI Official Symbol
Flt3l
NCBI Official Synonym Symbols
Ly72L; Flt3lg
NCBI Protein Information
fms-related tyrosine kinase 3 ligand
UniProt Protein Name
Fms-related tyrosine kinase 3 ligand
UniProt Gene Name
Flt3lg
UniProt Synonym Gene Names
Flt3l; Flt3 ligand; Flt3L
UniProt Entry Name
FLT3L_MOUSE
Uniprot Description
FLT3LG: Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cytokine; Ligand, receptor tyrosine kinase; Membrane protein, integral
Cellular Component: extracellular space; cell surface; membrane; plasma membrane; extracellular region; integral to membrane
Molecular Function: protein homodimerization activity; cytokine activity; receptor tyrosine kinase binding
Biological Process: positive regulation of natural killer cell differentiation; regulation of myeloid dendritic cell activation; lymphocyte differentiation; embryonic hemopoiesis; positive regulation of cell proliferation; positive regulation of protein amino acid phosphorylation; positive regulation of myoblast differentiation
Research Articles on Flt3-L
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Product Notes
The Flt3-L flt3lg (Catalog #AAA844745) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's flt-3-Ligand can be used in a range of immunoassay formats including, but not limited to, SDS-PAGE; HPLC. Researchers should empirically determine the suitability of the Flt3-L flt3lg for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "flt-3-Ligand, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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