IP-10 (CXCL10) active protein
Human IP-10 (CXCL10)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Jul 2008]
Uniprot Description
Function: Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3.
Subcellular location: Secreted.
Induction: By IFNG/IFN-gamma. A diverse population of cell types rapidly increases transcription of mRNA encoding this protein. This suggests that gamma-induced protein may be a key mediator of the IFNG/IFN-gamma response.
Post-translational modification: CXCL10(1-73) is produced by proteolytic cleavage after secretion from keratinocytes.
Sequence similarities: Belongs to the intercrine alpha (chemokine CxC) family.
Mass spectrometry: Molecular mass is 8641.8 Da from positions 22 - 98. Determined by ESI. Ref.5
Research Articles on IP-10 (CXCL10)
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Product Notes
The IP-10 (CXCL10) cxcl10 (Catalog #AAA691791) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Human IP-10 (CXCL10) reacts with Human and may cross-react with other species as described in the data sheet. The amino acid sequence is listed below: VPLSRTVRCT CISISNQPVN PRSLEKLEII PASQFCPRVE IIATMKKKGE KRCLNPESKA IKNLLKAVSK ERSKRSP. It is sometimes possible for the material contained within the vial of "IP-10 (CXCL10), Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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