PPIL4 active protein

Human Recombinant PPIL4

Cat. Num. AAA844582

• Gene Names: PPIL4; HDCME13P
• Applications: SDS-Page
• Purity: >=85%
• Synonyms: PPIL4; Human Recombinant PPIL4; Peptidyl-prolyl cis-trans isomerase-like 4; HDCME13P; Rotamase PPIL4; Cyclophilin-like protein PPIL4.; PPIL4 active protein

• Host: E Coli
• Purity/Purification: >=85%
• Form/Format: 0.5 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 2 mM DTT and 0.1 M NaCl. ; Appearance: Liquid
• Concentration: 0.5 mg/ml (varies by lot)
• Sequence: MGSSHHHHHH SSGLVPRGSH MAVLLETTLG DVVIDLYTEE RPRACLNFLK LCKIKYYNYC LIHNVQRDFI IQTGDPTGTG RGGESIFGQL YGDQASFFEA EKVPRIKHKK KGTVSMVNNG SDQHGSQFLI TTGENLDYLD GVHTVFGEVT EGMDIIKKIN ETFVDKDFVP YQDIRINHTV ILDDPFDDPP DLLIPDRSPE PTREQLDSGR IGADEEIDDF KGRSAEEVEE IKAEKEAKTQ AILLEMVGDL PDADIKPPEN VLFVCKLNPV TTDEDLEIIF SRFGPIRSCE VIRDWKTGES LCYAFIEFEK EEDCEKAFFK MDNVLIDDRR IHVDFSQSVA KVKWKGKGGK YTKSDFKEYE KEQDKPPNLV LKDKVKPKQD TKYDLILDEQ AEDSKSSHSH TSKKHKKKTH HCSEEKEDED YMPIKNTNQD IYREMGFGHY EEEESCWEKQ KSEKRDRTQN RSRSRSRERD GHYSNSHKSK YQTDLYERER SKKRDRSRSP KKSKDKEKSK YR
• Sequence Length: 492

• Applicable Applications for PPIL4 active protein: SDS-PAGE
• Biological Activity: Specific activity is > 190 nmoles/min/mg
• Unit Definition: Specific activity is defined as the amount of enzyme that cleaves 1 umole of Suc-AAFP-pNA per minute at 25 degree C in Tris-HCl pH 8.0 using chymotrypsin.
• Handling: Centrifuge the vial prior to opening.
• Preparation and Storage: At -80 degree C; Shelf Life: 12 months

Testing Data

Related Product Information for PPIL4 active protein

Background: PPIL4 is an evolutionarily conserved member of the cyclophilin-type PPIase family of proteins. Ubiquitously expressed with predominant expression in kidney, PPIL4 localizes to the nucleus and contains one PPIase cyclophilin-type domain, a lysine-rich domain, a pair of bipartite nuclear targeting sequences and one RRM (RNA recognition motif) domain. The presence of the RRM domain along with nuclear targeting sequences suggests that PPIL4 may be involved in transcriptional regulation.

Product Categories/Family for PPIL4 active protein

Proteins and Enzymes; Proteins and Enzymes (A-Z)  

NCBI and Uniprot Product Information

• NCBI GI #: 20911035
• NCBI GeneID: 85313
• NCBI Accession #: NP_624311.1
• NCBI GenBank Nucleotide #: NM_139126.3
• UniProt Accession #: Q8WUA2; Q7Z3Q5; B2RD34
• Molecular Weight: 59.4 kDa
• NCBI Official Full Name: peptidyl-prolyl cis-trans isomerase-like 4
• NCBI Official Synonym Full Names: peptidylprolyl isomerase (cyclophilin)-like 4
• NCBI Official Symbol: PPIL4
• NCBI Official Synonym Symbols: HDCME13P
• NCBI Protein Information: peptidyl-prolyl cis-trans isomerase-like 4
• UniProt Protein Name: Peptidyl-prolyl cis-trans isomerase-like 4
• Protein Family: Peptidyl-prolyl cis-trans isomerase
• UniProt Gene Name: PPIL4
• UniProt Synonym Gene Names: PPIase
• UniProt Entry Name: PPIL4_HUMAN

NCBI Description

This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. [provided by RefSeq, Jul 2008]

Uniprot Description

PPIL4: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.

Protein type: RNA-binding; EC 5.2.1.8; Isomerase; Cyclophilin

Chromosomal Location of Human Ortholog: 6q25.1

Cellular Component: nucleus

Molecular Function: peptidyl-prolyl cis-trans isomerase activity; nucleotide binding

Biological Process: protein peptidyl-prolyl isomerization; protein folding