FKBP3 active protein

Human Recombinant FKBP3

Cat. Num. AAA844944

• Applications: SDS-Page
• Purity: >=90%
• Synonyms: FKBP3; Human Recombinant FKBP3; FK506 binding protein 3; FKBP25; PPIase FKBP3; Rotamase; FKBP3 active protein

• Host: E Coli
• Purity/Purification: >=90%
• Form/Format: 1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT and 10% glycerol.; Appearance: Liquid
• Concentration: 1 mg/ml (varies by lot)
• Sequence: MAAAVPQRAW TVEQLRSEQL PKKDIIKFLQ EHGSDSFLAE HKLLGNIKNV AKTANKDHLV TAYNHLFETK RFKGTESISK VSEQVKNVKL NEDKPKETKS EETLDEGPPK YTKSVLKKGD KTNFPKKGDV VHCWYTGTLQ DGTVFDTNIQ TSAKKKKNAK PLSFKVGVGK VIRGWDEALL TMSKGEKARL EIEPEWAYGK KGQPDAKIPP NAKLTFEVEL VDID
• Sequence Length: 224

• Applicable Applications for FKBP3 active protein: SDS-PAGE
• Biological Activity: Specific activity is > 490 nmoles/min/mg.
• Unit Definition: Specific activity is > 490 nmoles/min/mg, and is defined as the amount of enzyme that cleaves 1 umole of suc-AAFP-pNA per minute at 25 degree C in Tris HCl pH 8.0 using chymotrypsin.
• Handling: Centrifuge the vial prior to opening.
• Preparation and Storage: At -80 degree C; Shelf Life: 12 months

Testing Data

Related Product Information for FKBP3 active protein

Background: FKBP3 is part of a family of immunosuppressant receptors which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. FKBP3 accelerates the folding of proteins. FKBP3 is part of the immunophilin protein family, which participates in immunoregulation and fundamental cellular processes concerning protein folding and trafficking. FKBP3 is a cis-trans prolyl isomerase enzyme that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a greater affinity for rapamycin than for FK506 and therefore is a significant protein for immunosuppression by rapamycin.

Product Categories/Family for FKBP3 active protein

Proteins and Enzymes; Proteins and Enzymes (A-Z)  

NCBI and Uniprot Product Information

• NCBI GI #: 4503727
• NCBI GeneID: 2287
• NCBI Accession #: NP_002004.1
• NCBI GenBank Nucleotide #: NM_002013.3
• UniProt Accession #: Q00688; Q14317; B2R4Q9
• Molecular Weight: 25.1 kDa
• NCBI Official Full Name: peptidyl-prolyl cis-trans isomerase FKBP3
• UniProt Protein Name: Peptidyl-prolyl cis-trans isomerase FKBP3
• Protein Family: FK506-binding protein
• UniProt Gene Name: FKBP3
• UniProt Synonym Gene Names: FKBP25; PPIase FKBP3; 25 kDa FKBP; FKBP-25; FKBP-3
• UniProt Entry Name: FKBP3_HUMAN

NCBI Description

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq, Sep 2008]

Uniprot Description

FKBP3: FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. PPIases accelerate the folding of proteins. Belongs to the FKBP-type PPIase family.

Protein type: EC 5.2.1.8; Isomerase

Chromosomal Location of Human Ortholog: 14q21.2

Cellular Component: endoplasmic reticulum membrane; nucleus

Molecular Function: protein binding; FK506 binding; peptidyl-prolyl cis-trans isomerase activity; receptor activity

Biological Process: protein peptidyl-prolyl isomerization