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Testing Data

PPIL1 active protein

Human Recombinant PPIL1

Gene Names
PPIL1; CYPL1; hCyPX; PPIase; CGI-124
Applications
SDS-Page
Purity
>=95%
Synonyms
PPIL1; Human Recombinant PPIL1; Peptidylprolyl isomerase (cyclophilin)-like 1; Rotamase; CGI-124; CYPL1; hCyPX; PPIase.; PPIL1 active protein
Ordering
For Research Use Only!
Host
E Coli
Purity/Purification
>=95%
Form/Format
1 mg/ml solution in 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol.
Appearance: Liquid
Concentration
1 mg/ml (varies by lot)
Sequence
MAAIPPDSWQ PPNVYLETSM GIIVLELYWK HAPKTCKNFA ELARRGYYNG TKFHRIIKDF MIQGGDPTGT GRGGASIYGK QFEDELHPDL KFTGAGILAM ANAGPDTNGS QFFVTLAPTQ WLDGKHTIFG RVCQGIGMVN RVGMVETNSQ DRPVDDVKII KAYPSGLEHH HHHH
Sequence Length
166
Applicable Applications for PPIL1 active protein
SDS-PAGE
Biological Activity
Specific activity is > 300 nmoles/min/mg.
Unit Definition
Specific activity is defined as the amount of enzyme that cleaves 1 umole of Suc-AAFP-pNA per minute at 25 degree C in Tris-HCl pH 8.0 using chymotrypsin.
Handling
Centrifuge the vial prior to opening.
Preparation and Storage
At -80 degree C
Shelf Life: 12 months

Testing Data

Testing Data
Related Product Information for PPIL1 active protein
Background: Peptidylprolyl isomerase (cyclophilin)-like 1, also known as PPIL1, is a member of peptidyl-propyl cis trans isomerase (PPIase) family, which catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerates the folding of proteins. Human PPIL1 might play an important role in proliferation of cancer cells through modulation of phosphorylation of stathmin. So it can be developed as a novel molecular target for colon-cancer therapy.
Product Categories/Family for PPIL1 active protein

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
19.3 kDa
NCBI Official Full Name
peptidyl-prolyl cis-trans isomerase-like 1
NCBI Official Synonym Full Names
peptidylprolyl isomerase (cyclophilin)-like 1
NCBI Official Symbol
PPIL1
NCBI Official Synonym Symbols
CYPL1; hCyPX; PPIase; CGI-124
NCBI Protein Information
peptidyl-prolyl cis-trans isomerase-like 1
UniProt Protein Name
Peptidyl-prolyl cis-trans isomerase-like 1
UniProt Gene Name
PPIL1
UniProt Synonym Gene Names
CYPL1; PPIase
UniProt Entry Name
PPIL1_HUMAN

NCBI Description

This gene is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved, ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. Based on similarity to other PPIases, this protein could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. [provided by RefSeq, Jul 2008]

Uniprot Description

PPIL1: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing. Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.

Protein type: EC 5.2.1.8; Spliceosome; Isomerase; Cyclophilin

Chromosomal Location of Human Ortholog: 6p21.1

Molecular Function: protein binding; peptidyl-prolyl cis-trans isomerase activity

Biological Process: nuclear mRNA splicing, via spliceosome; protein peptidyl-prolyl isomerization; protein folding

Research Articles on PPIL1

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Product Notes

The PPIL1 ppil1 (Catalog #AAA844404) is an Active Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's PPIL1 can be used in a range of immunoassay formats including, but not limited to, SDS-PAGE. Researchers should empirically determine the suitability of the PPIL1 ppil1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MAAIPPDSWQ PPNVYLETSM GIIVLELYWK HAPKTCKNFA ELARRGYYNG TKFHRIIKDF MIQGGDPTGT GRGGASIYGK QFEDELHPDL KFTGAGILAM ANAGPDTNGS QFFVTLAPTQ WLDGKHTIFG RVCQGIGMVN RVGMVETNSQ DRPVDDVKII KAYPSGLEHH HHHH. It is sometimes possible for the material contained within the vial of "PPIL1, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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