CRELD1 recombinant protein

Recombinant Mouse CRELD1 Protein (ECD, Fc Tag)

Cat. Num. AAA2546645

• Gene Names: Creld1; i11E7; AI843811
• Purity: > 95 % as determined by SDS-PAGE
• Synonyms: CRELD1; Recombinant Mouse CRELD1 Protein (ECD; Fc Tag); AI843811; CRELD1 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: > 95 % as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS,5% Trehalose, 5% Mannitol, 0.01 % Tween-80, pH 7.4.
• Sequence: Met1-Glu362

• Application Notes: The recombinant mouse Creld1 consists 571 amino acids and predicts a molecular mass of 63 kDa.
• Species: Mouse
• Tag: C-Fc
• Endotoxin: < 1.0 EU per ug of the protein as determined by the LAL method.
• Reconstitution: It is recommended that sterile water (800uL) be added to the vial to prepare a stock solution of 0.25mg/mL. Concentration is measured by UV-Vis.
• Preparation and Storage: Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. This product is provided as lyophilized powder which is shipped with ice packs.

SDS-PAGE

Related Product Information for CRELD1 recombinant protein

CRELD1 is a transmembrane glycoprotein. Epidermal growth factor(EGF)like domain exists in CRELD1. EGF-like repeats are a class of cysteine-rich domains that mediate interactions between proteins of diverse function. EGF domains are found in proteins that are either completely secreted or have transmembrane regions that tether the protein to the cell surface. CRELD1 contains a 333 amino acid acid (aa) extracellular domain (ECD), two tandem transmembrane segments, and a second ECD of 15 aa. Defects in CRELD1 may cause susceptibility to atrioventricular septal defect type 2 which results in a persistent common atrioventricular canal.

NCBI and Uniprot Product Information

• NCBI GI #: 19527148
• NCBI GeneID: 171508
• NCBI Accession #: NP_598691.1
• NCBI GenBank Nucleotide #: NM_133930.2
• UniProt Accession #: Q91XD7; Q8BGJ8
• Molecular Weight: Mol_Mass: 63 kDa
• NCBI Official Full Name: cysteine-rich with EGF-like domain protein 1
• NCBI Official Synonym Full Names: cysteine-rich with EGF-like domains 1
• NCBI Official Symbol: Creld1
• NCBI Official Synonym Symbols: i11E7; AI843811
• NCBI Protein Information: cysteine-rich with EGF-like domain protein 1
• UniProt Protein Name: Cysteine-rich with EGF-like domain protein 1
• Protein Family: Cysteine-rich with EGF-like domain protein
• UniProt Gene Name: Creld1

Uniprot Description

CRELD1: Defects in CRELD1 may be the cause of susceptibility to atrioventricular septal defect type 2 (AVSD2). AVSD is a spectrum of cardiac malformations that result in a persistent common atrioventricular canal. The complete form of AVSD involves underdevelopment of the lower part of the atrial septum and the upper part of the ventricular septum. A less severe form, known as partial AVSD or ostium primum atrial septal defect has a deficiency of the atrial septum. Complete AVSD are clinically apparent at birth, whereas less severe forms, such as an isolated cleft mitral valve or small defects of the atrial or ventricular septa may go undetected. Belongs to the CRELD family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 6 E3|6 52.77 cM