CRELD1 recombinant protein

Recombinant Mouse CRELD1 Protein (His tag)

Cat. Num. AAA2546644

• Gene Names: Creld1; i11E7; AI843811
• Purity: > 95 % as determined by SDS-PAGE
• Synonyms: CRELD1; Recombinant Mouse CRELD1 Protein (His tag); CRELD1 recombinant protein

• Host: Human Cells
• Purity/Purification: > 95 % as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH 7.4
• Sequence Length: 420

• Application Notes: The recombinant mouse CRELD1 comprises 344 amino acids and has a predicted molecular mass of 37.7 kDa. The apparent molecular mass of the protein is approximately 48 kDa in SDS-PAGE under reducing conditions.
• Predicted N Terminal: Gln 30
• Endotoxin: < 1.0 EU per mug of the protein as determined by the LAL method
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -70 degree C

SDS-PAGE

Related Product Information for CRELD1 recombinant protein

Background: CRELD1 is a transmembrane glycoprotein. Epidermal growth factor (EGF)-like domain exists in CRELD1. EGF-like repeats are a class of cysteine-rich domains that mediate interactions between proteins of diverse function. EGF domains are found in proteins that are either completely secreted or have transmembrane regions that tether the protein to the cell surface. CRELD1 contains a 333 amino acid acid (aa) extracellular domain (ECD), two tandem transmembrane segments, and a second ECD of 15 aa. Defects in CRELD1 may cause susceptibility to atrioventricular septal defect type 2 which results in a persistent common atrioventricular canal.

Description: A DNA sequence encoding the mouse CRELD1 (NP_598691.1) (Met1-Glu362) was expressed with a C-terminal polyhistidine tag.

NCBI and Uniprot Product Information

• NCBI GI #: 19527148
• NCBI GeneID: 171508
• NCBI Accession #: NP_598691.1
• NCBI GenBank Nucleotide #: NM_133930.2
• UniProt Accession #: Q91XD7; Q8BGJ8
• Molecular Weight: 45,718 Da
• NCBI Official Full Name: cysteine-rich with EGF-like domain protein 1
• NCBI Official Synonym Full Names: cysteine-rich with EGF-like domains 1
• NCBI Official Symbol: Creld1
• NCBI Official Synonym Symbols: i11E7; AI843811
• NCBI Protein Information: cysteine-rich with EGF-like domain protein 1
• UniProt Protein Name: Cysteine-rich with EGF-like domain protein 1
• Protein Family: Cysteine-rich with EGF-like domain protein
• UniProt Gene Name: Creld1

Uniprot Description

CRELD1: Defects in CRELD1 may be the cause of susceptibility to atrioventricular septal defect type 2 (AVSD2). AVSD is a spectrum of cardiac malformations that result in a persistent common atrioventricular canal. The complete form of AVSD involves underdevelopment of the lower part of the atrial septum and the upper part of the ventricular septum. A less severe form, known as partial AVSD or ostium primum atrial septal defect has a deficiency of the atrial septum. Complete AVSD are clinically apparent at birth, whereas less severe forms, such as an isolated cleft mitral valve or small defects of the atrial or ventricular septa may go undetected. Belongs to the CRELD family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 6 E3|6 52.77 cM