RNF128 cdna clone
RNF128 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Uniprot Description
RNF128: E3 ubiquitin-protein ligase that catalyzes polyubiquitin chains. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription and this activity is likely to be mediated by E3 ligase activity. Plays an important role in the induction of the anergic phenotype. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural- inducing signals. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 6.3.2.-; Membrane protein, integral; Ubiquitin conjugating system; EC 6.3.2.19; Ligase; Ubiquitin ligase
Chromosomal Location of Human Ortholog: Xq22.3
Molecular Function: protein binding
Biological Process: regulation of protein stability
Research Articles on RNF128
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Product Notes
The RNF128 rnf128 (Catalog #AAA1268014) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggggccgc cgcctggggc cggggtctcc tgccgcggtg gctgcggctt ttccagattg ctggcatggt gcttcctgct ggccctgagt ccgcaggcac ccggttcccg gggggctgaa gcagtgtgga ccgcgtacct caacgtgtcc tggcgggttc cgcacacggg agtgaaccgt acggtgtggg agctgagcga ggagggcgtg tacggccagg actcgccgct ggagcctgtg gctggggtcc tggtaccgcc cgacgggccc ggggcgctta acgcctgtaa cccgcacacg aatttcacgg tgcccacggt ttggggaagc accgtgcaag tctcttggtt ggccctcatc caacgcggcg ggggctgcac cttcgcagac aagatccatc tggcttatga gagaggggcg tctggagccg tcatctttaa cttccccggg acccgcaatg aggtcatccc catgtctcac ccgggtgcag tagacattgt tgcaatcatg atcggcaatc tgaaaggcac aaaaattctg caatctattc aaagaggcat acaagtgaca atggtcatag aagtagggaa aaaacatggc ccttgggtga atcactattc aatttttttc gtttctgtgt ccttttttat tattacggcg gcaactgtgg gctattttat cttttattct gctcgaaggc tacggaatgc aagagctcaa agcaggaagc agaggcaatt aaaggcagat gctaaaaaag ctattggaag gcttcaacta cgcacactga aacaaggaga caaggaaatt ggccctgatg gagatagttg tgctgtgtgc attgaattgt ataaaccaaa tgatttggta cgcatcttaa cgtgcaacca tattttccat aagacatgtg ttgacccatg gctgttagaa cacaggactt gccccatgtg caaatgtgac atactcaaag ctttgggaat tgaggtggat gttgaagatg gatcagtgtc tttacaagtc cctgtatcca atgaaatatc taatagtgcc tcctcccatg aagaggataa tcgcagcgag accgcatcat ctggatatgc ttcagtacag ggaacagatg aaccgcctct ggaggaacac gtgcagtcaa caaatgaaag tctacagctg gtaaaccatg aagcaaattc tgtggcagtg gatgttattc ctcatgttga caacccaacc tttgaagaag acgaaactcc taatcaagag actgctgttc gagaaattaa atcttaa. It is sometimes possible for the material contained within the vial of "RNF128, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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