JAZF1 cdna clone

JAZF1

Cat. Num. AAA200886

• Synonyms: JAZF1; TIP27; ZNF802; JAZF1 cdna clone

• Form/Format: Lyophilized
• Sequence: Nucleotide Sequence: ATGACAGGCATCGCCGCCGCCTCCTTCTTCTCCAATACCTGCCGATTCGGGGGCTGCGGACTCCACTTCCCCACCCTGGCCGACCTCATCGAGCACATCGAGGACAACCACATCGATACAGATCCACGGGTTTTAGAAAAACAAGAATTACAGCAGCCAACCTATGTTGCCCTGAGTTACATAAATAGATTCATGACAGATGCTGCCCGCCGAGAGCAGGAGTCCCTAAAGAAGAAGATTCAGCCGAAGCTCTCGCTGACTCTGTCCAGCTCAGTGTCTCGAGGGAATGTGTCCACTCCCCCACGCCACAGCAGTGGAAGCCTTACTCCCCCCGTGACCCCACCCATCACCCCCTCCTCTTCATTCCGCAGCAGCACTCCGACAGGCAGCGAGTATGACGAGGAGGAGGTGGACTATGAGGAGTCGGACAGCGATGAGTCCTGGACCACAGAGAGTGCCATCAGCTCCGAAGCCATCCTCAGCTCCATGTGCATGAATGGAGGGGAAGAGAAGCCTTTTGCCTGCCCAGTTCCTGGATGTAAAAAGAGATACAAGAATGTGAATGGCATAAAGTATCACGCTAAGAATGGTCACAGAACACAGATTCGTGTCCGCAAACCATTCAAGTGTCGCTGTGGGAAGAGTTACAAGACAGCTCAGGGCCTGCGGCACCACACAATCAATTTCCATCCCCCGGTGTCGGCTGAGATTATCAGGAAGATGCAGCAATAA; ; Translation Sequence: MTGIAAASFF SNTCRFGGCG LHFPTLADLI EHIEDNHIDT DPRVLEKQEL QQPTYVALSYINRFMTDAAR REQESLKKKI QPKLSLTLSS SVSRGNVSTP PRHSSGSLTP PVTPPITPSSSFRSSTPTGS EYDEEEVDYE ESDSDESWTT ESAISSEAIL SSMCMNGGEE KPFACPVPGCKKRYKNVNGI KYHAKNGHRT QIRVRKPFKC RCGKSYKTAQ GLRHHTINFH PPVSAEIIRKMQQ
• Sequence Length: 243

• Species: Human
• Chromosome Location: 7p15.2-p15.1
• OMIM Reference Number: 606246
• cDNA Size: 732bp
• Vector Description: This shuttle vector contains the complete ORF. It is inseted BamH I to Hind III. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.
• Vector: (puc19-derived cloning vector)
• Preparation Before Usage: 1. Centrifuge at 7000rpm for 1 minute. 2. Carefully open the vial and add 100ul of sterile water to dissolve the DNA. Each tube contains approximately 10ug of lyophilized plasmid.
• Preparation and Storage: Store the plasmid at -20 degree C.

Related Product Information for JAZF1 cdna clone

JAZF1 is a nuclear protein with three C2H2-type zinc fingers, and functions as a transcriptional repressor. Chromosomal aberrations involving JAZF1 are associated with endometrial stromal tumors. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Product Categories/Family for JAZF1 cdna clone

Epigenomics (Transcription & Translation)

NCBI and Uniprot Product Information

• NCBI GI #: 91822911
• NCBI Accession #: NP_778231.2
• NCBI GenBank Nucleotide #: NM_175061.3
• UniProt Accession #: Q86VZ6
• NCBI Official Full Name: juxtaposed with another zinc finger protein 1
• UniProt Protein Name: Juxtaposed with another zinc finger protein 1
• Protein Family: Juxtaposed with another zinc finger protein
• UniProt Gene Name: JAZF1
• UniProt Synonym Gene Names: TIP27; ZNF802
• UniProt Entry Name: JAZF1_HUMAN

Uniprot Description

JAZF1: Potential transcription factor. A chromosomal aberration involving JAZF1 may be a cause of endometrial stromal tumors. Translocation t(7;17)(p15;q21) with SUZ12. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: C2H2-type zinc finger protein; Oncoprotein; Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 7p15.2-p15.1

Cellular Component: transcriptional repressor complex; nucleus

Molecular Function: nucleic acid binding; metal ion binding; transcription corepressor activity

Biological Process: transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter