JAZF1 recombinant protein

JAZF1, 1-243aa, Human His tag, E Coli (Denatured)

Cat. Num. AAA205380

• Gene Names: JAZF1; TIP27; ZNF802
• Applications: SDS-Page
• Purity: > 85% by SDS-PAGE
• Synonyms: JAZF1; 1-243aa; Human His tag; E Coli (Denatured); juxtaposed with another zinc finger protein 1; TIP27; ZNF802; JAZF1 recombinant protein

• Host: E Coli
• Purity/Purification: > 85% by SDS-PAGE
• Form/Format: Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 0.4M urea, 10% glycerol
• Concentration: 1 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSMTGIAAA SFFSNTCRFG GCGLHFPTLA DLIEHIEDNH IDTDPRVLEK QELQQPTYVA LSYINRFMTD AARREQESLK KKIQPKLSLT LSSSVSRGNV STPPRHSSGS LTPPVTPPIT PSSSFRSSTP TGSEYDEEEV DYEESDSDES WTTESAISSE AILSSMCMNG GEEKPFACPV PGCKKRYKNV NGIKYHAKNG HRTQIRVRKP FKCRCGKSYK TAQGLRHHTI NFHPPVSAEI IRKMQQ
• Sequence Length: 243

• Applicable Applications for JAZF1 recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for JAZF1 recombinant protein

JAZF1 is a nuclear protein with three C2H2-type zinc fingers, and functions as a transcriptional repressor. Chromosomal aberrations involving this gene are associated with endometrial stromal tumors. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. Recombinant human JAZF1 protein, fused to His-tag at N-terminus, was expressed in E Coli.

Product Categories/Family for JAZF1 recombinant protein

Epigenomics

References

Langberg,K.A., et al. (2012) J. Hum. Genet. 57 (1), 57-61; Nucci,M.R., et al. (2007) Am. J. Surg. Pathol. 31 (1), 65-70;

NCBI and Uniprot Product Information

• NCBI GI #: 91822911
• NCBI GeneID: 221895
• NCBI Accession #: NP_778231
• NCBI GenBank Nucleotide #: NM_175061.3
• UniProt Accession #: Q86VZ6; Q8N3L7; A4D195
• Molecular Weight: 29.5kDa (266aa)
• NCBI Official Full Name: juxtaposed with another zinc finger protein 1
• NCBI Official Synonym Full Names: JAZF zinc finger 1
• NCBI Official Symbol: JAZF1
• NCBI Official Synonym Symbols: TIP27; ZNF802
• NCBI Protein Information: juxtaposed with another zinc finger protein 1
• UniProt Protein Name: Juxtaposed with another zinc finger protein 1
• Protein Family: Juxtaposed with another zinc finger protein
• UniProt Gene Name: JAZF1
• UniProt Synonym Gene Names: TIP27; ZNF802

NCBI Description

This gene encodes a nuclear protein with three C2H2-type zinc fingers, and functions as a transcriptional repressor. Chromosomal aberrations involving this gene are associated with endometrial stromal tumors. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized [provided by RefSeq, Jul 2008]

Uniprot Description

Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2 (PubMed:15302918). Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity (). Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD (). Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue (). Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity ().