ECE2 cdna clone
ECE2 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the M13 family, which includes type 2 integral membrane metallopeptidases. The encoded enzyme is a membrane-bound zinc-dependent metalloprotease. The enzyme catalyzes the cleavage of big endothelin to produce the vasoconstrictor endothelin-1, and plays a role in the processing of several neuroendocrine peptides. It may also have methyltransferase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Uniprot Description
ECE2: Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit beta- amyloid peptide accumulation in brain. May also have methyltransferase activity. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Methyltransferase; Methyltransferase, protein arginine, predicted; Protease; Vesicle; Membrane protein, integral; EC 3.4.24.71
Chromosomal Location of Human Ortholog: 3q27.1
Cellular Component: cytoplasmic vesicle membrane
Molecular Function: metalloendopeptidase activity; protein binding
Biological Process: brain development; cardioblast differentiation; cell-cell signaling; heart development; peptide hormone processing
Research Articles on ECE2
Similar Products
Product Notes
The ECE2 ece2 (Catalog #AAA1266214) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggcctctc caggggcagg tagggcgcct ccggagttac cggagcggaa ctgcgggtac cgcgaagtcg agtactggga tcagcgctac caaggcgcag ccgattctgc cccctacgat tggttcgggg acttctcctc cttccgtgcc ctcctagagc cggagctgcg gcccgaggac cgtatccttg tgctaggttg cgggaacagt gccctgagct acgagctgtt cctcggaggc ttccctaatg tgaccagtgt ggactactca tcagtcgtgg tggctgccat gcaggctcgc tatgcccatg tgccgcagct gcgctgggag accatggatg tgcggaagct ggacttcccc agtgcttctt ttgatgtggt gctcgagaag ggcacgctgg atgccctgct ggctggggaa cgagatccct ggaccgtgtc ctctgaaggt gtccacactg tggaccaggt gttgagtgag gtgagccgcg tgcttgtccc tggaggccgg tttatctcaa tgacttctgc tgccccccac tttcggacca gacactatgc ccaagcctat tatggctggt ccctgaggca tgctacctat ggcagcggtt tccacttcca tctctacctc atgcacaagg gcgggaagct cagtgtggcc cagctggctc tgggggccca aatcctctca ccccccagac ctcccacctc accttgcttc cttcaggact cagatcatga ggacttcctt agtgccattc agctctga. It is sometimes possible for the material contained within the vial of "ECE2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
